Fatal Tuberculosis in a Free-Ranging African Elephant and One Health Implications of Human Pathogens in Wildlife
Fatal Tuberculosis in a Free-Ranging African Elephant and One Health Implications of Human Pathogens in Wildlife
复制标题
DOI：
10.3389/fvets.2019.00018
复制
发表时间：
2019-02-06
影响因子：
3.2
通讯作者：
van Helden, Paul
中科院分区：
文献类型：
--
作者：
Miller, Michele A.;Buss, Peter;van Helden, Paul
人类结核病（TB）是全球公共卫生问题，结核分枝杆菌（Mtb）感染和疾病的动物病例的发现，特别是在多宿主环境中，也对公共卫生，兽医疾病控制和保护工作具有重要意义。本文描述了在人类结核病高负担地区的一只自由放养的非洲象（Loxodonta africana）中发生的结核病致死病例。尸检显示广泛的肉芽肿性肺炎，从中分离出Mtb并鉴定为LAM 3/F11谱系的成员;这是南非人类中发现的常见谱系。这些研究结果是在全球野生动物中新出现的结核病的框架内进行的，并强调了“一个健康”范式在解决这种对野生动物的人畜共患病威胁和人畜共患病影响方面的重要性。
Tuberculosis (TB) in humans is a global public health concern and the discovery of animal cases of Mycobacterium tuberculosis (Mtb) infection and disease, especially in multi-host settings, also has significant implications for public health, veterinary disease control, and conservation endeavors. This paper describes a fatal case of Mtb disease in a free-ranging African elephant (Loxodonta africana) in a high human TB burden region. Necropsy revealed extensive granulomatous pneumonia, from which Mtb was isolated and identified as a member of LAM3/F11 lineage; a common lineage found in humans in South Africa. These findings are contextualized within a framework of emerging Mtb disease in wildlife globally and highlights the importance of the One Health paradigm in addressing this anthroponotic threat to wildlife and the zoonotic implications.