Coeliac disease and risk of schizophrenia and other psychosis: A general population cohort study
Coeliac disease and risk of schizophrenia and other psychosis: A general population cohort study
复制标题
DOI：
10.1080/00365520600863472
复制
发表时间：
2007-02-01
影响因子：
1.9
通讯作者：
Montgomery, Scott M.
中科院分区：
文献类型：
--
作者：
Ludvigsson, Jonas F.;Osby, Urban;Montgomery, Scott M.
客观的。一些病例报告和最近一项关于乳糜泻 (CD) 和精神分裂症家族史的研究表明 CD 与精神分裂症之间存在联系。我们研究的目的是确定全国普通人群队列中克罗恩病患者发生非情感性精神病的风险。材料和方法。我们在 1973 年至 2003 年间，在瑞典国家住院患者登记册中确定了 14,003 名被诊断为 CD 的个体。然后，瑞典统计局从人口登记册中确定了 5 名与诊断时的年龄和日历年份、性别和县相匹配的参考个体 (n 68,125)。只有在首次记录 CD 诊断后随访超过一年的个体或参考个体的相应日期才纳入分析。通过 Cox 回归估计 CD 患者随后发生非情感性精神病的风险。结果。 CD 与任何非情感性精神病的风险显着增加相关（风险比 (HR) 1.555 95% CI = 1.16-2.06；p = 0.003）（14,003 名 CD 患者中有 65 个阳性事件，68,125 名无 CID 的患者中有 216 个阳性事件），这种风险增加主要是由于与非精神分裂症非情感性精神病的关联（HR = 1.61；95% Cl = 1.19-2.20；p = 0.002：CD 患者中有 56 个阳性事件，参考个体中有 180 个阳性事件）。与随后的精神分裂症没有统计学上的显着关联（HR = 1.43；95% = 0.77-2.67）- p = 0.261：CD 患者中有 14 个阳性事件，参考个体中有 50 个阳性事件）。结论。患有 CID 的人患非情感性精神病的风险可能会增加。
Objective. Several case reports and a recent study on coeliac disease (CD) and family history of schizophrenia indicate a link between CD and schizophrenia. The objective of our study was to determine the risk of non-affective psychosis in patients with CD in a national general population cohort. Material and methods. We identified 14,003 individuals with a diagnosis of CD in the Swedish national inpatient register between 1973 and 2003. From the population register, Statistics Sweden then identified five reference individuals matched for age and calendar year at diagnosis, gender and county (n 68,125). Only individuals with more than one year of follow-up after the CD diagnosis was first recorded or a corresponding date in reference individuals were included in the analyses. The risk of subsequent non-affective psychosis in individuals with CD was estimated by Cox regression. Results. CD was associated with a statistically significant increased risk of any non-affective psychosis (hazard ratio (HR) 1.555 95% CI = 1.16-2.06; p =0.003) (65 positive events in 14,003 individuals with CD and 216 positive events in 68,125 individuals without CID),- this increased risk was largely due to the association with non-schizophrenic non-affective psychosis (HR = 1.61; 95% Cl = 1.19-2.20; p 0.002: 56 positive events in individuals with CD and 180 among reference individuals). There was no statistically significant association with subsequent schizophrenia (HR = 1.43; 95% =0.77-2.67)- p 0.261: 14 positive events in individuals with CD and 50 among reference individuals). Conclusions. Individuals with CID may be at increased risk of non-affective psychosis.