IMMUNOSUPPRESSION BY EMBRYONIC LIVER CELLS
IMMUNOSUPPRESSION BY EMBRYONIC LIVER CELLS
复制标题
胚胎肝细胞的免疫抑制
DOI：
10.1097/00007890-197512000-00006
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发表时间：
1975
期刊：
影响因子：
6.2
通讯作者：
T. Umiel
中科院分区：
文献类型：
--
作者：
A. Globerson;T. Umiel
研究发现，胚胎和新生小鼠的肝细胞会干扰混合淋巴细胞培养 (MLC) 反应，通过靶细胞释放 51Cr 或 3H-胸苷掺入来测量细胞毒性。在两个实验系统中，当刺激细胞与肝脏供体同源或无关时，都会出现抑制。此外，在体外，18 天胚胎和新生儿肝细胞被发现会干扰 α-二硝基苯基-聚-L-赖氨酸 (α-DNP-PLL) 抗体的产生。这些发现符合这样的假设：胚胎细胞可以主动抑制免疫反应，从而防止可能的自我反应。
Liver cells from embryonic and newborn mice were found to interfere with mixed lymphocyte culture (MLC) reactions measuring either cytotoxicity by 51Cr release from target cells or 3H-thymidine incorporation. In both experimental systems a suppression was noted when the stimulator cells were syngeneic or unrelated to the liver donor. In addition, 18-day embryonic and neonatal liver cells were found to interfere with production of antibodies to α-dinitrophenyl-poly-L-lysine (α-DNP-PLL) in vitro. These findings conform with the hypothesis that embryonic cells can actively suppress immune reactions and thereby prevent a possible response to self.