A PHYLLOTACTIC APPROACH TO THE STRUCTURE OF COLLAGEN FIBRILS
A PHYLLOTACTIC APPROACH TO THE STRUCTURE OF COLLAGEN FIBRILS
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DOI：
10.1142/s1793048011001245
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发表时间：
2011-06-01
期刊：
影响因子：
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通讯作者：
Sadoc, Jean-Francois
中科院分区：
文献类型：
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作者：
Charvolin, Jean;Sadoc, Jean-Francois
胶原原纤维是由长生物分子组成的缆索状组合物，即所谓的三螺旋，是结缔组织的主要成分。它们在形态和功能上的决定性作用促使人们对它们的形成和结构进行了大量的研究。然而，这两点仍然是有待解决的问题，特别是关于三螺旋结构的横向组合的问题，它当然是密集的，但严格来说，这不是一个有序的分子晶体。我们在这里检查由分节趋向性算法提供的几何模板，该算法在圆柱对称的情况下为点或平行杆的装配中的每个元素提供最均匀和各向同性的密集环境。从胶原原纤维中三螺旋的层状分布得到的散射强度可以解释其x射线模式沿赤道方向的散射。按照这种方法，原纤维中的三螺旋聚集应该在软凝聚态物质研究的框架内考虑，而不是在分子晶体研究的框架内考虑。
Collagen fibrils, cable-like assemblies of long biological molecules, the so-called triple helices, are dominant components of connective tissues. Their determinant morphological and functional roles motivated a large number of studies concerning their formation and structure. However, these two points are still open questions and, particularly, that of the lateral assembly of the triple helices which is certainly dense but not strictly that of a well-ordered molecular crystal. We examine here the geometrical template provided by the algorithm of phyllotaxis which gives to each element of an assembly of points or parallel rods the most homogeneous and isotropic dense environment in a situation of cylindrical symmetry. The scattered intensity obtained from a phyllotactic distribution of triple helices in collagen fibrils presents features which could contribute to the scattering observed along the equatorial direction of their X-ray patterns. Following this approach, the aggregation of triple helices in fibrils should be considered within the frame of soft condensed matter studies rather than that of molecular crystal studies.