Antibiotic prescribing and antibiotic resistance in community practice: retrospective study, 1996-8
Antibiotic prescribing and antibiotic resistance in community practice: retrospective study, 1996-8
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DOI：
10.1136/bmj.319.7219.1239
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发表时间：
1999-11-06
影响因子：
105.7
通讯作者：
Howard, AJ
中科院分区：
文献类型：
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作者：
Magee, JT;Pritchard, EL;Howard, AJ
方法和结果收集班戈、卡迪夫和瑞尔公共卫生实验室以及东格拉摩根、查尔斯王子和雷克瑟姆马勒医院的全科医生诊断尿路感染的常规尿液样本中大肠菌群对抗生素的敏感性数据。从威尔士处方定价服务获得手术处方实践的数据，计算每次手术的处方率（每年每1000名患者的处方数量）和耐药率（排除来自同一患者的具有相同敏感性的多种分离生物）。不含β内酰胺酶抑制剂的广谱青霉素制剂（如氨苄西林和阿莫西林）的使用情况通过从所有其他广谱青霉素的处方总数中减去共阿莫西林的处方数来估计。下面我们使用术语阿莫西林来指代这些不含β内酰胺酶抑制剂的广谱青霉素。
Methods and resultsData on the susceptibility to antibiotics of coliform organisms in routine urine samples taken by general practitioners for diagnosis of urinary tract infections were collected from the Bangor, Cardiff, and Rhyl Public Health Laboratories and the East Glamorgan, Prince Charles, and Wrexham Maelor Hospitals. Data on the prescribing practices of surgeries were obtained from the Welsh Prescription Pricing Service Rates of prescribing (the number of prescriptions/1000 patients per year) and resistance rates (which excluded multiple isolates of organisms with the same susceptibility from the same patient) were calculated for each surgery. The use of broad spectrum penicillin formulations without a β lactamase inhibitor (such as ampicillin and amoxicillin) was estimated by subtracting the number of prescriptions for co-amoxiclav from the total number of prescriptions for all other broad spectrum penicillins. We use the term amoxicillin below to refer to these broad spectrum penicillins without a β lactamase inhibitor.