Time restricted feeding provides a viable alternative to alternate day fasting when evaluated in terms of redox homeostasis in rats
Time restricted feeding provides a viable alternative to alternate day fasting when evaluated in terms of redox homeostasis in rats
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DOI：
10.1016/j.archger.2020.104188
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发表时间：
2020-11-01
影响因子：
4
通讯作者：
Rizvi, Syed Ibrahim
中科院分区：
文献类型：
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作者：
Bhoumik, Sukanya;Kumar, Raushan;Rizvi, Syed Ibrahim
间歇性禁食（IF）是一种用于干预不同生物体衰老的非药物饮食方法。我们通过测量氧化还原参数来评估限时饮食方案和隔日禁食在大鼠中的有效性，氧化还原参数经常被用作衰老的标志性生物标志物。将Wistar大鼠（8个月）分为三组，每组6只大鼠。I组：对照组; II组：限时喂养（TRF）（分别以16：8 h的比例进食和禁食）; III组。隔日喂养（ADF）（隔日进食和禁食），持续1个月。测定抗氧化防御和氧化应激的生物标志物：FRAP、GSH、PMRS、ROS、AGE、MDA、PCO、AOPP、TNF-α和IL-6。我们的研究结果表明，基于主要的衰老生物标志物，TRF对大鼠的氧化还原稳态方面的评估相比，ADF具有类似的效果。观察到的结果捍卫了我们的目的，ADF和TRF方法是可靠的饮食限制方案，并随后改善大鼠的代谢特征和氧化还原稳态。
Intermittent fasting (IF) is a non-pharmacological dietary approach for intervening into aging in different organisms. We evaluated the efficacy of time restricted dietary regimen and alternate-day fasting in rats by measuring redox parameters which are frequently used as signature biomarkers of aging. Wistar rats (8 months) were divided into three groups of six rats each. Group I: Control; Group II: Time-restricted feeding (TRF) (fed and fasted at a ratio of 16:8 h respectively) and Group III. Alternate day feeding (ADF) (fed and fasted on alternate days), for a period of 1 month. The biomarkers of antioxidant defense and oxidative stress: FRAP, GSH, PMRS, ROS, AGE, MDA, PCO, AOPP, TNF-alpha and IL-6, were determined. Our results suggest that, based on predominant aging biomarkers, TRF has a similar effect on rats compared with ADF evaluated in terms of redox homeostasis. Observed results defend our purpose that the ADF and TRF methods are reliable dietary restriction regimens and subsequently improve the metabolic profile and redox homeostasis in rats.