Increased phagocytic NADPH oxidase activity associates with coronary artery calcification in asymptomatic men
Increased phagocytic NADPH oxidase activity associates with coronary artery calcification in asymptomatic men
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DOI：
10.1080/10715762.2017.1321745
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发表时间：
2017-01-01
影响因子：
3.3
通讯作者：
Zalba, Guillermo
中科院分区：
文献类型：
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作者：
Beloqui, Oscar;Moreno, Maria U.;Zalba, Guillermo
血管钙化是动脉粥样硬化的常见特征，与心血管事件有关。氧化应激可能参与了血管钙化的发病机制。先前的研究表明，吞噬细胞的NADPH氧化酶与动脉粥样硬化有关。本研究的目的是探讨吞噬细胞NADPH氧化酶介导的超氧化物歧化产物与冠状动脉钙(CAC)的关系。用化学发光法测定159例无明显临床动脉粥样硬化的无症状男性的NADPH氧化酶介导的超氧化物歧化产物，并用计算机断层扫描测定CAC。用多元线性回归分析CAC与NADPH氧化酶介导的超氧化物歧化的关系。与CAC得分最低的个体(=0个Agatston单位)相比，得分较高的个体(>；400个Agatston单位)表现出更高的超氧化物歧化产物(p<；0.05)。在相关分析中，超氧物生成与CAC呈正相关(p<；0.01)，在多因素分析中，在调整了年龄、高密度脂蛋白、甘油三酯、体重指数、吸烟、动脉高血压和糖尿病后，CAC仍然显著。总而言之，在没有临床表现的动脉粥样硬化性疾病的男性人群中，NADPH氧化酶介导的超氧化物产生增加与CAC增强相关。尽管这些发现是描述性的，但表明吞噬NADPH氧化酶介导的氧化应激可能参与了CAC的发生。
Vascular calcification is a common feature in atherosclerosis and associates with cardiovascular events. Oxidative stress may be involved in the pathogenesis of vascular calcification. Previous studies have shown that the phagocytic NADPH oxidase is associated with atherosclerosis. The objective of the present study was to investigate the association between phagocytic NADPH oxidase-mediated superoxide production and coronary artery calcium (CAC). NADPH oxidase-mediated superoxide production was determined by chemiluminescence and CAC by computed tomography in 159 asymptomatic men free of overt clinical atherosclerosis. Multivariate linear regression analyses were used to assess the relationship between CAC and NADPH oxidase-mediated superoxide production. Compared with individuals in the lowest score of CAC (= 0 Agatston units), those in the upper score (> 400 Agatston units) showed higher superoxide production (p < 0.05). In correlation analysis, superoxide production positively (p < 0.01) correlated with CAC, which in multivariate analysis remained significant after adjusting for age, HDL-cholesterol, triglycerides, body mass index, smoking, arterial hypertension and diabetes mellitus. In conclusion, in a population of men without clinically overt atherosclerotic disease, increased NADPH oxidase-mediated superoxide production associated with enhanced CAC. Albeit descriptive, these findings suggest a potential involvement of phagocytic NADPH oxidase-mediated oxidative stress in CAC.