Dietary fatty acids and the 5-year incidence of age-related maculopathy
Dietary fatty acids and the 5-year incidence of age-related maculopathy
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DOI：
10.1001/archopht.124.7.981
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发表时间：
2006-07-01
影响因子：
--
通讯作者：
Mitchell, Paul
中科院分区：
文献类型：
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作者：
Chua, Brian;Flood, Victoria;Mitchell, Paul
目的：为了评估纵向饮食脂肪和事件年龄相关性黄斑病变（ARM）在老年人，人口为基础的，historicalcohol.Methods：共3654人，49岁或以上，参加了蓝山眼科研究（1992年至1994年）之间的关联; 2335（75.1%的幸存者）5年后（1997年至1999年）进行复查。通过半定量食物频率调查问卷收集了2895人（79%）的饮食数据，以计算膳食脂肪摄入量。根据视网膜照片（威斯康星州ARM分级系统）对ARM的存在进行分级。Logistic回归校正年龄，性别，维生素C摄入量，和smoking.Results：参与者与最高的n-3多不饱和脂肪摄入量的五分位数与最低的风险较低的事件早期ARM（比值比[95%置信区间]，0.41 [0.22-0.75]）。每周至少食用一次鱼可使早期ARM的发生率降低40%（比值比[95%置信区间]，0.58 [0.370.90]），而每周至少食用3次鱼可降低晚期ARM的发生率（比值比[95%置信区间]，0.25 [0.06-1.00]）。我们没有发现事件ARM和黄油，人造黄油，或nut consumption.Conclusions之间的关联：有规律的饮食高的n-3多不饱和脂肪，特别是从鱼，建议保护早期和晚期ARM在这个老年澳大利亚队列。我们的研究无法证实其他临床研究报告的多不饱和脂肪摄入量过高的有害影响。
Objective: To assess longitudinal associations between dietary fat and incident age-related maculopathy (ARM) in an older, population-based, historical cohort.Methods: A total of 3654 persons, 49 years or older, participated in the Blue Mountains Eye Study (1992-1994); 2335 (75.1% of survivors) were reexamined after 5 years (1997-1999). Dietary data were collected from 2895 people (79%) at baseline by means of a semiquantitative food frequency questionnaire to calculate dietary fat intakes. Presence of ARM was graded from retinal photographs (Wisconsin ARM Grading System). Logistic regression adjusted for age, sex, vitamin C intake, and smoking.Results: Participants with the highest vs lowest quintiles of n-3 polyunsaturated fat intake had lower risk of incident early ARM (odds ratio [95% confidence interval], 0.41 [0.22-0.75). A 40% reduction of incident early ARM was associated with fish consumption at least once a week (odds ratio [95% confidence interval], 0.58 [0.370.90]), whereas fish consumption at least 3 times per week could reduce the incidence of late ARM (odds ratio [95% confidence interval], 0.25 [0.06-1.00]). We found no association between incident ARM and butter, margarine, or nut consumption.Conclusions: A regular diet high in n-3 polyunsaturated fat, especially from fish, suggests protection against early and late ARM in this older Australian cohort. Our study could not confirm deleterious effects of higher polyunsaturated fat intakes reported by other clinic-based studies.