Proinflammatory cytokine levels in hyperlipidemic patients with periodontitis after periodontal treatment
Proinflammatory cytokine levels in hyperlipidemic patients with periodontitis after periodontal treatment
复制标题
DOI：
10.1111/j.1601-0825.2011.01880.x
复制
发表时间：
2012-04-01
期刊：
影响因子：
3.8
通讯作者：
Sert, T.
中科院分区：
文献类型：
--
作者：
Fentoglu, O.;Kirzioglu, F. Y.;Sert, T.
目的：本研究的目的是评估牙周治疗对高脂血症牙周炎患者血清和龈沟液（GCF）中促炎细胞因子水平的影响。材料和方法：52例高脂血症和牙周炎患者和28例全身健康的牙周炎对照（C）被纳入本研究。高脂血症组分为两组，即建议饮食组（HD）和他汀类药物组（HS）。在基线和完成非手术牙周治疗（包括刮治和根面平整）后3个月随访（3 MFU）时，获得临床牙周参数、空腹静脉血和GCF样本，并评估血清肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）1-β和IL-6水平。结果：HS组探诊出血百分比显著高于HD组和C组。在HD和HS组中，血清IL-6和GCFTNF-a水平在3 MFU与基线之间显著降低。HS组在研究结束时GCF IL-6也显著降低。结论：牙周治疗和降血脂治疗的结合可能会对高脂血症的代谢和炎症控制产生有益的影响。口腔疾病（2012）18，299-306
OBJECTIVE: The aim of this study was to evaluate the effects of periodontal treatment on serum and gingival crevicular fluid (GCF) proinflammatory cytokine levels in hyperlipidemic patients with periodontitis. MATERIALS AND METHODS: Fifty-two patients with hyperlipidemia and periodontitis and 28 systemically healthy controls with periodontitis (C) were included in the study. Hyperlipidemic groups were divided into two groups as suggested diet (HD) and prescribed statin (HS). The clinical periodontal parameters, fasting venous blood, and GCF samples were obtained, and serum tumor necrosis factor-alpha (TNF-a), interleukin (IL) 1-beta, and IL-6 levels were evaluated at baseline and at 3 months follow-up (3MFU) after the completion of the non-surgical periodontal treatment that included scaling and root planning. RESULTS: Percentage of bleeding on probing was significantly higher in the HS group than both the HD and C groups. In the HD and HS groups, there were significant decreases in serum IL-6 andGCFTNF-a levels between the 3MFUand baseline. Asignificant decrease was also found in GCF IL-6 at the end of the study period in the HS group. CONCLUSION: The combination of the periodontal therapy and antilipemic treatment may provide beneficial effects on the metabolic and inflammatory control of hyperlipidemia. Oral Diseases (2012) 18, 299-306