Bone response to immediate loading through titanium implants with different surface roughness in rats
Bone response to immediate loading through titanium implants with different surface roughness in rats
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DOI：
10.1007/s10266-013-0107-4
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发表时间：
2013
期刊：
影响因子：
2.5
通讯作者：
Naoko Sato;Toshie Kuwana;Miou Yamamoto;H. Suenaga;T. Anada;S. Koyama;O. Suzuki;K. Sasaki
中科院分区：
文献类型：
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作者：
Naoko Sato;Toshie Kuwana;Miou Yamamoto;H. Suenaga;T. Anada;S. Koyama;O. Suzuki;K. Sasaki
由于其成功的高可预测性，种植体治疗是一种可靠的治疗缺失的牙齿。即刻植入的概念在早期美学和功能恢复方面已被广泛接受。然而，几乎没有生物学证据支持这一概念。本研究的目的是研究机械载荷和即刻加载钛种植体表面粗糙度对大鼠骨形成的相互作用。螺旋形阳极氧化钛植入物要么未经处理（光滑），要么酸蚀。在大鼠胫骨内平行插入两个植入物，立即施加封闭线圈弹簧（2.0 N）。使用显微层析成像分析两种植入物周围的骨小梁和皮质骨，并在第1、2和4周进行移除扭矩测试。立即加载酸蚀种植体导致骨矿物质密度、接触表面积和骨皮质厚度显著降低。在立即加载光滑种植体后，没有观察到这些影响。相反，负载不影响酸蚀种植体固定；然而，在第1周，平滑的植入物固定明显减少。这些结果表明，表面粗糙度调节骨对机械应力的反应，并且在愈合后期，立即加载可能不会抑制光滑和粗糙种植体的骨整合。
Because of its high predictability of success, implant therapy is a reliable treatment for replacement of missing teeth. The concept of immediate implant loading has been widely accepted in terms of early esthetic and functional recovery. However, there is little biological evidence to support this concept. The objective of this study was to examine the interactive effects of mechanical loading and surface roughness of immediately loaded titanium implants on bone formation in rats. Screw-shaped anodized titanium implants were either untreated (smooth) or acid-etched. Two implants were inserted parallel to each other in the tibiae of rats, and a closed coil spring (2.0 N) was immediately applied. Trabecular and cortical bone around both implants was analyzed using microtomographic images, and a removal torque test was performed at weeks 1, 2, and 4. Immediate loading of acid-etched implants resulted in significant decreases in bone mineral density, contact surface area, and cortical bone thickness. These effects were not observed after immediate loading of smooth implants. Conversely, loading did not influence acid-etched implant fixation; however, smooth implant fixation at week 1 was significantly reduced. These results imply that surface roughness regulates bone response to mechanical stress and that immediate loading might not inhibit osseointegration for smooth and rough implants in the late healing stages.