Analysis of discrete phenotypes using a multipoint identity-by-descent method: application to Alzheimer's disease.
Analysis of discrete phenotypes using a multipoint identity-by-descent method: application to Alzheimer's disease.
复制标题
使用多点血统同一性方法分析离散表型：应用于阿尔茨海默病。
DOI：
10.1002/gepi.1370100609
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发表时间：
1993
影响因子：
2.1
通讯作者：
Gholami,K
中科院分区：
文献类型：
--
作者：
Goldgar,DE;Lewis,CM;Gholami,K
开发了多点血统同一性方法，通过划分遗传方差来检测与特定染色体区域的连锁。该方法之前已应用于数量性状，这里扩展到质量性状，其中通过合并协变量将二分受影响/未受影响的状态变量转换为数量变量。该方法应用于遗传分析研讨会 8 的阿尔茨海默病数据集，以研究与 19 号和 21 号染色体的假定连锁。多点血统同一性方法用于测试通过定性性状的连锁，以及受影响同胞之间染色体区域的过度共享。将结果与受影响谱系成员方法和经典连锁分析的结果进行比较。这些方法都没有给出显示明确关联的结果，只有使用多点血统同一性方法的 19 号染色体上的波士顿数据集和 21 号染色体上的杜克数据集出现了略微显着的结果。 © 1993 Wiley-Liss, Inc.
The multipoint identity‐by‐descent method was developed to detect linkage to a specific chromosomal region through partitioning the genetic variance. This method has previously been applied to quantitative traits, and here is extended to a qualitative trait, where a dichotomous affected/unaffected status variable is transformed to a quantitative variable by incorporating covariates. This method is applied to the Alzheimer's disease data sets from Genetic Analysis Workshop 8, to investigate putative linkage to chromosomes 19 and 21. The multipoint identity‐by‐descent method is used to test for linkage through the qualitative trait, and for excess sharing of the chromosomal region among affected sibs. Results are compared to those of the affected‐pedigree‐member method and classical linkage analysis. None of these methods gave results showing clear linkage, with the only marginally significant results occurring for the Boston data set on chromosome 19 and the Duke data set for chromosome 21 using the multipoint identity‐by‐descent method. © 1993 Wiley‐Liss, Inc.