Electrospinning Cargo-Containing Polyelectrolyte Complex Fibers: Correlating Molecular Interactions to Complex Coacervate Phase Behavior and Fiber Formation
Electrospinning Cargo-Containing Polyelectrolyte Complex Fibers: Correlating Molecular Interactions to Complex Coacervate Phase Behavior and Fiber Formation
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DOI：
10.1021/acs.macromol.8b01709
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发表时间：
2018-11-13
期刊：
影响因子：
5.5
通讯作者：
Perry, Sarah L.
中科院分区：
文献类型：
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作者：
Meng, Xiangxi;Schiffman, Jessica D.;Perry, Sarah L.
我们首次展示了将货物直接封装到聚电解质复合物 (PEC) 纤维垫中的技术。这种方法利用复杂凝聚层固有的自组装特性来简化对含有高负载和均匀分布的货物的静电纺丝纤维的配方要求。两个结构相似的荧光染料家族被用作不同疏水性和电荷的模型货物，并被封装到聚（4-苯乙烯磺酸钠盐）和聚（二烯丙基二甲基氯化铵）的凝聚层中。系统地研究了凝聚层相行为、染料分配和所得纤维作为染料和盐浓度的函数。有利的静电和π-π相互作用促进了强分配，但盐的增加却受到不利影响。我们进一步确定，染料和盐的相互作用可以被视为独立的控制参数，以调节凝聚层前体溶液的性质和电纺性。这些发现促进了电纺 PEC 纤维在生物医学、能源和需要装载垫子的分离相关应用中的使用。
We present the first demonstration of the direct encapsulation of cargo into polyelectrolyte complex (PEC) fiber mats. This approach takes advantage of the intrinsic self-assembly characteristics of complex coacervates to simplify the formulation requirements to electrospin fibers containing a high loading and an even distribution of cargo. Two families of structurally similar fluorescent dyes were used as model cargo of varying hydrophobicity and charge and were encapsulated into coacervates of poly(4-styrenesulfonic acid, sodium salt) and poly(diallyldimethylammonium chloride). The coacervate phase behavior, dye partitioning, and resulting fibers were systematically investigated as a function of dye and salt concentration. Strong partitioning was facilitated by favorable electrostatic and pi-pi interactions but was adversely affected by increased salt. We further identified that dye and salt interactions can be treated as independent control parameters to modulate the properties and electrospinnability of the coacervate precursor solutions. These findings facilitate the use of electrospun PEC fibers in applications related to biomedicine, energy, and separations where cargo-loaded mats are needed.