Lipid raft redox signaling platforms in vascular dysfunction: Features and mechanisms
Lipid raft redox signaling platforms in vascular dysfunction: Features and mechanisms
复制标题
血管功能障碍中的脂筏氧化还原信号平台：特征和机制
DOI：
10.1007/s11883-009-0034-6
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发表时间：
2009-05-01
影响因子：
5.8
通讯作者：
Zhou, Fan
中科院分区：
文献类型：
--
作者：
Jin, Si;Zhou, Fan
脂筏在跨膜信号转导中起着重要作用。在死亡因子刺激后，单个LR聚集以在血管内皮细胞中募集NADPH氧化酶亚基和相关蛋白，形成LR氧化还原信号平台，这最终导致内皮细胞中活性氧的产生增加和内皮功能受损。从机制上讲，由溶酶体酸性鞘磷脂酶水解鞘磷脂产生的神经酰胺自发融合形成富含神经酰胺的大结构域，这是LR氧化还原信号平台形成的关键因素。这些LR信号平台在病理性损伤后内皮功能障碍或损伤的发展中起重要作用。
Lipid rafts (LRs) play essential roles in transmembrane signal transduction. Upon death factor stimulation, individual LRs cluster to recruit NADPH oxidase subunits and related proteins in vascular endothelial cells, forming LR redox signaling platforms, which ultimately results in increased production of reactive oxygen species in endothelial cells and impaired endothelial function. Mechanistically, ceramide generated from the hydrolysis of sphingomyelin by lysosomal acid sphingomyelinase spontaneously fuses to form ceramide-enriched macrodomains, which are critical contributors to the formation of LR redox signaling platforms. These LR signaling platforms play important roles in the development of endothelial dysfunction or injury upon pathologic insults.