FAMILY HISTORY AND PROSTATE-CANCER RISK IN BLACK, WHITE, AND ASIAN MEN IN THE UNITED-STATES AND CANADA
FAMILY HISTORY AND PROSTATE-CANCER RISK IN BLACK, WHITE, AND ASIAN MEN IN THE UNITED-STATES AND CANADA
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DOI：
10.1093/oxfordjournals.aje.a117495
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发表时间：
1995-04-15
影响因子：
5
通讯作者：
STAMEY, T
中科院分区：
文献类型：
--
作者：
WHITTEMORE, AS;WU, AH;STAMEY, T
有前列腺癌家族史的男性患前列腺癌的风险增加在流行病学研究中得到了一致的观察。然而，大多数研究都局限于白人男性；对于前列腺癌在发病率异常高的人群（如非裔美国人）或低发病率人群（如亚裔美国人）中常见的聚集性知之甚少。作者报告了一项基于人群的前列腺癌病例对照研究的结果，研究对象包括美国和加拿大的黑人、白人和亚裔美国人。对照按年龄（5岁组）、种族（黑人、白人、华裔美国人、日裔美国人）和居住地区（洛杉矶、旧金山、夏威夷、温哥华、多伦多）匹配病例。在联合组的参与者中，5%的对照组和13%的病例报告父亲、兄弟或儿子患有前列腺癌。这些患病率在亚裔美国人中略低于黑人或白人。阳性的家族史与统计学上显著的两到三倍的风险增加有关。根据年龄和种族调整后，与此类家族史相关的总体优势比为2.5（95%可信区间为1.9-3.3）。这个比值比不因参与者的种族和年龄而变化。1087名对照者的血清用于检测家族史与血清雄激素和前列腺特异性抗原浓度之间的关系。性激素结合球蛋白的浓度在有家族病史的男性中略高于没有家族病史的男性。前列腺特异性抗原浓度与家族史无关。
Increased risk of prostate cancer in men with a family history of the disease has been observed consistently in epidemiologic studies. However, most studies have been confined to white men; little is known about familiar aggregation of prostate cancer in populations with unusually high incidence, such as African Americans, or in populations with low incidence, such as Asian-Americans. The authors report results from a population-based case-control study of prostate cancer among blacks, whites, and Asian-Americans in the United States and Canada. Controls were matched to cases on age (5-year groups), ethnicity (black, white, Chinese-American, Japanese-American), and region of residence (Los Angeles, San Francisco, Hawaii, Vancouver, Toronto). In the combined group of participants, 5% of controls and 13% of cases reported a father, brother, or son with prostate cancer. These prevalences were somewhat lower among Asian-Americans than among blacks or whiles. A positive family history was associated with a statistically significant two- to threefold increase in risk in each of the three ethnic groups. The overall odds ratio associated with such a family history, adjusted for age and ethnicity, was 2.5 (95% confidence interval 1.9-3.3). This odds ratio varied by neither ethnicity nor age of the participants. Sera from 1,087 controls were used to examine the relations between family history and serum concentrations of androgens and prostate-specific antigen. The concentrations of sex hormone-binding globulin were slightly higher in men with than without a positive family history. Prostate-specific antigen concentrations were unrelated to family history.