Smaller auditory P300 amplitude in schizophrenics in remission.
Smaller auditory P300 amplitude in schizophrenics in remission.
复制标题
缓解期精神分裂症患者的听觉 P300 振幅较小。
作者：
K. M. Rao;C. V. Ananthnarayanan;B. Gangadhar;N. Janakiramaiah
使用听觉奇怪范式记录 12 名（6 名男性）精神分裂症 (DSM-IIIR) 患者（处于严格定义的临床缓解期）的 P300 事件相关电位 (ERP)。还在 10 名（5 名男性）年龄、性别和教育程度匹配的对照受试者中记录了 ERP。在 Cz 和 Pz 记录位点测量 ERP 潜伏期和振幅。精神分裂症缓解期患者的 P300 平均潜伏期在 Cz [343.6 +/- 31 (SD) ms] 和 Pz (346.15 +/- 30 ms) 时与正常人没有差异（Cz：332.8 +/- 23 ms，Pz：323 +/- 38 ms）。缓解期精神分裂症患者在 Cz (9.2 +/- 4.4 microV) 和 Pz (8.8 +/- 4.4 microV) 处的 P300 ERP 振幅显着小于正常人 (Cz: 13.3 +/- 2.90 microV; Pz: 12.71 +/- 4.18 microV)。讨论了较小的听觉 P300 振幅在精神分裂症中的意义。
The P300 event-related potential (ERP) was recorded using the auditory oddball paradigm in 12 (6 male) schizophrenic (DSM-IIIR) patients in rigorously defined clinical remission. The ERP was also recorded in 10 (5 male) age-, sex- and education-matched control subjects. ERP latencies and amplitude were measured at Cz and Pz recording sites. Mean latencies of the P300 in schizophrenic patients in remission at Cz [343.6 +/- 31 (SD) ms] and Pz (346.15 +/- 30 ms) did not differ from those of normals (Cz: 332.8 +/- 23 ms, Pz: 323 +/- 38 ms). The P300 ERP amplitude was significantly (p < 0.05) smaller in schizophrenics in remission at both Cz (9.2 +/- 4.4 microV) and Pz (8.8 +/- 4.4 microV) than in normals (Cz: 13.3 +/- 2.90 microV; Pz: 12.71 +/- 4.18 microV). The significance of the smaller auditory P300 amplitude in schizophrenia is discussed.