Rapid, continuous cycling and psychiatric co-morbidity in pediatric bipolar I disorder
Rapid, continuous cycling and psychiatric co-morbidity in pediatric bipolar I disorder
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DOI：
10.1034/j.1399-5618.2001.30405.x
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发表时间：
2001-08-01
影响因子：
5.4
通讯作者：
Calabrese, JR
中科院分区：
文献类型：
--
作者：
Findling, RL;Gracious, BL;Calabrese, JR
目的：本研究的主要目的是描述儿童和青少年中 I 型双相情感障碍 (BP-I) 的临床表现，并评估两个年龄组中 BP-I 的表现是否相似。 方法：本研究纳入了 90 名年龄在 5 岁至 17 岁之间、符合 BP-I 完全诊断症状标准的青少年。这些青少年的 BP-I 诊断是根据半结构化诊断访谈的结果以及儿童和青少年精神科医生的临床评估得出的。使用生命图法（LCM）评估了这些年轻人的一部分疾病的病程。还获得了有关临床表现、纵向病史、精神共病和父母精神病理学的数据。结果：BP-I 的临床表现在儿童和青少年中相似。符合 BP-I 诊断标准的青少年在情绪高涨或烦躁期间平均会出现 7 种躁狂症状中的约 5.8 种。 BP-I 被发现是一种周期性疾病，其特征是快速循环率高 (50%)，且几乎没有发作间恢复。这些受试者中近 75% 也符合破坏性行为障碍的诊断症状标准。父亲中情绪障碍的发生率较高。结论：这些数据表明，青少年 BP-I 的表现是一种周期性且有效的临床病症，其表现与该疾病的后期发病形式具有连续性。
Objectives: The primary purpose of this study was to describe the clinical presentation of bipolar I disorder (BP-I) as it occurs in children and adolescents and to assess whether the manifestations of BP-I were similar in both age groups.Method: Ninety youths between the ages of 5 and 17 years meeting full diagnostic symptom criteria for BP-I were included in this study. The diagnosis of BP-I was established for these youths based on the results of a semi-structured diagnostic interview and a clinical assessment by a child and adolescent psychiatrist. The course of a subset of these youngsters' illnesses was assessed using the Life Charting Method (LCM). Data regarding the clinical presentation, longitudinal history, psychiatric co-morbidities and parental psychopathology were also obtained.Results: The clinical presentation of BP-I was similar in children and adolescents. Youths meeting diagnostic criteria for BP-I developed an average of approximately 5.8 of the 7 symptoms of mania during periods of elevated or irritable mood. BP-I was found to be a cyclic disorder characterized by high rates of rapid cycling (50%) with almost no inter-episode recovery. Almost 75% of these subjects also met diagnostic symptom criteria for a disruptive behavior disorder. High rates of mood disorders were found in fathers.Conclusions: These data suggest that the presentation of juvenile BP-I is a cyclic and valid clinical condition with manifestations on a continuum with the later-onset forms of this illness.