Annexin A10 expression correlates with serrated pathway features in colorectal carcinoma with microsatellite instability
Annexin A10 expression correlates with serrated pathway features in colorectal carcinoma with microsatellite instability
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DOI：
10.1111/apm.12284
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发表时间：
2014-12-01
期刊：
影响因子：
2.8
通讯作者：
Kang, Gyeong Hoon
中科院分区：
文献类型：
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作者：
Kim, Jung Ho;Rhee, Ye-Young;Kang, Gyeong Hoon
膜联蛋白A10（ANXA 10）最近被确定为结直肠无蒂锯齿状腺瘤/息肉的标志物。尽管锯齿状瘤形成途径被认为与大多数微卫星不稳定性高（MSI-H）散发性结直肠癌（CRC）有关，但CRC中ANXA 10表达的临床病理意义尚不清楚。在此，我们通过免疫组织化学方法评估了168例MSI-H CRC中ANXA 10的表达状态。在168例MSI-H CRC中，肿瘤细胞中ANXA 10的核染色显示28例（17%）ANXA 10阳性（ANXA 10+）肿瘤。大多数ANXA 10+肿瘤位于近端结肠（96%，p
Annexin A10 (ANXA10) has recently been identified as a marker of sessile serrated adenomas/polyps of the colorectum. Although the serrated neoplasia pathway is thought to be involved in the majority of microsatellite instability-high (MSI-H) sporadic colorectal carcinomas (CRCs), the clinicopathological implications of ANXA10 expression in CRC are unknown. Here, we evaluated ANXA10 expression status in 168 MSI-H CRCs by immunohistochemistry. Among 168 MSI-H CRCs, nuclear staining for ANXA10 in tumor cells revealed 28 cases (17%) with ANXA10-positive (ANXA10+) tumors. Most of the ANXA10+ tumors were located in the proximal colon (96%, p