Effect of stimulation of the subthalamic nucleus on oral control of patients with parkinsonism
Effect of stimulation of the subthalamic nucleus on oral control of patients with parkinsonism
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DOI：
10.1136/jnnp.67.3.329
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发表时间：
1999-09-01
影响因子：
11
通讯作者：
Benabid, AL
中科院分区：
文献类型：
--
作者：
Gentil, M;Garcia-Ruiz, P;Benabid, AL
Objectives-To assess the oral system of parkinsonian patients treated with chronic stimulation of bilateral subthalamic nucleus（STN）to evaluate accurately the effectiveness of this procedure on the articulatory organs. Methods-Load sensitive programmerlevers were used to sample ramp and hold force contractions generated by the upper lip，lower lip，and tongue.受试者被给予指令，以响应屏幕上出现的目标信号（范围从0.25到2 N），尽可能快速和准确地产生力。还测量了每个效应器官的最大力。14名健康对照受试者和10名患者参加了这项研究。经过一夜的快速的患者进行了评估，在两种条件下，在早上：在双边刺激和1小时后，停止tuberculostimulation.Results-During tuberculostimulosis，动态和静态控制的发音器官得到了改善：发音器官的最大强度，他们的准确性，达到目标，和精度的举行阶段增加。此外，斜坡相的反应时间和上升时间减少。患者的语音评估项目18的统一帕金森氏病评定量表（MERS）大大提高了电刺激的dream. Conclusion-Improvement的刺激患者的口腔控制表明，dreamstimulation调制参与语音的神经元结构。然而，为了更全面地了解这种手术对语言的影响，必须对更多的患者进行评估。
Objectives-To assess the oral system of parkinsonian patients treated with chronic stimulation of the bilateral subthalamic nucleus (STN) to evaluate precisely the effectiveness of this procedure on the articulatory organs.Methods-Load sensitive cantilevers were used to sample ramp and hold force contractions generated by the upper lip, lower lip, and tongue. The subject was given the instruction to produce forces as rapidly and as accurately as possible in response to the target signal (ranging from 0.25 to 2 N), which appeared on a screen. Maximal force of each effector organ was also measured. Fourteen healthy control subjects and 10 patients participated in this study. After an overnight fast the patients were evaluated in the morning under two conditions: during bilateral stimulation and 1 hour after stopping STN stimulation.Results-During STN stimulation, dynamic and static control of the articulatory organs were improved: the maximal strength of the articulatory organs, their accuracy to reach the target, and the precision of the hold phase increased. In addition, the reaction time and the rise time of the ramp phase decreased. Patients' speech as assessed by the item 18 of the unified Parkinson's disease rating scale (UPDRS) was greatly improved by electrical stimulation of the STN.Conclusions-Improvement of oral control of the stimulated patients suggests that STN stimulation modulates neuronal structures involved in speech. However, more patients have to be evaluated for a fuller understanding of the effect of this surgical procedure on speech.