Concordance for multiple sclerosis in Danish twins: an update of a nationwide study
Concordance for multiple sclerosis in Danish twins: an update of a nationwide study
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DOI：
10.1191/1352458505ms1220oa
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发表时间：
2005-10-01
影响因子：
5.8
通讯作者：
Kyvik, KO
中科院分区：
文献类型：
--
作者：
Hansen, T;Skytthe, A;Kyvik, KO
此前尚未在完整的全国数据集中研究过双胞胎中多发性硬化症 (MS) 的发生。丹麦几乎完整的多发性硬化症和双胞胎登记系统确保了可以获得双胞胎多发性硬化症病例的基本无偏见的样本。在这项基于人群的研究中，几乎所有 1983 年之前出生、1948 年之后发病、1997 年 1 月 1 日之前诊断的丹麦多发性硬化症双胞胎病例均被确定。在 13 286 例 MS 病例中，178 例是双胞胎，其中 164 对不和谐双胞胎，7 对一致双胞胎。我们发现同卵双胞胎的先证者一致性显着高于异卵双胞胎，估计单卵双胞胎的先证者一致性为 24%（95% 置信区间 (CI)：5 - 39%），异卵双胞胎为 3%（95% CI：0 - 8%）。因此，同卵双胞胎的同卵双胞胎患有多发性硬化症的风险为 24%，而异卵双胞胎的相应风险仅为 3%。我们的结果在很大程度上证实了之前发表的一致性估计，并表明遗传因素在多发性硬化症的易感性中发挥着重要作用。
The occurrence of multiple sclerosis ( MS) in twins has not previously been studied in complete nationwide data sets. The existence of almost complete MS and twin registries in Denmark ensures that essentially unbiased samples of MS cases among twins can be obtained. In this population-based study, virtually all Danish MS cases among twins born before 1983 with onset of MS after 1948 and diagnosis before 1 January 1997 were identified. Of 13 286 MS cases, 178 were twins and, of these 164 twin pairs were discordant and seven were concordant. We found significantly higher proband-wise concordance among monozygotic twins than dizygotic twins, with estimated proband-wise concordances of 24% (95% confidence interval ( CI): 5 - 39%) for monozygotic and 3% ( 95% CI: 0 - 8%) for dizygotic twins. Thus, a monozygotic twin whose co-twin has MS has a 24% risk of developing the disease, while the corresponding risk for a dizygotic twin is only 3%. Our results largely confirm previously published concordance estimates and indicate that genetic factors are of importance in susceptibility to MS.