Progress of the COVID-19 vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escape.
Progress of the COVID-19 vaccine effort: viruses, vaccines and variants versus efficacy, effectiveness and escape.
复制标题
DOI：
10.1038/s41577-021-00592-1
复制
发表时间：
2021-10
期刊：
影响因子：
--
通讯作者：
Pierce BF
中科院分区：
文献类型：
--
作者：
Tregoning JS;Flight KE;Higham SL;Wang Z;Pierce BF
在2020年，针对严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的疫苗以前所未有的速度进行了开发和测试，2021年上半年，许多国家推出了疫苗。在这篇《进展》文章中，我们提供了正在进行的疫苗效力研究的快照，以及有关疫苗有效性和令人担忧的病毒变种的影响的真实数据。在成年人口中部署的疫苗比例很高，目前批准的疫苗在预防新冠肺炎，特别是严重疾病方面非常有效。尽管如此，在确保全球范围内公平获得疫苗以及为控制这场大流行和下一次大流行吸取经验教训方面仍然存在重大挑战。这篇进展文章根据正在进行的疫苗效力研究和疫苗有效性的真实数据，包括令人关注的病毒变种的影响和全球部署面临的挑战，提供了新冠肺炎疫苗努力的最新情况。
Where 2020 saw the development and testing of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at an unprecedented pace, the first half of 2021 has seen vaccine rollout in many countries. In this Progress article, we provide a snapshot of ongoing vaccine efficacy studies, as well as real-world data on vaccine effectiveness and the impact of virus variants of concern. Where they have been deployed in a high proportion of the adult population, the currently approved vaccines have been extremely effective in preventing COVID-19, particularly severe disease. Nonetheless, there are still significant challenges in ensuring equitable vaccine access around the globe and lessons that can be learned for controlling this pandemic and for the next pandemic. This Progress article provides an update on the COVID-19 vaccine effort in the light of ongoing vaccine efficacy studies and real-world data on vaccine effectiveness, including the impact of virus variants of concern and challenges for global deployment.
登录
查看更多内容
DOI：
10.1056/nejmoa2104840
发表时间：
2021-06-03
期刊：
The New England journal of medicine
影响因子：
--
作者：
Greinacher A;Thiele T;Warkentin TE;Weisser K;Kyrle PA;Eichinger S
通讯作者：
Eichinger S
DOI：
10.1016/s2468-2667(21)00055-4
发表时间：
2021-05
期刊：
The Lancet. Public health
影响因子：
--
作者：
Graham MS;Sudre CH;May A;Antonelli M;Murray B;Varsavsky T;Kläser K;Canas LS;Molteni E;Modat M;Drew DA;Nguyen LH;Polidori L;Selvachandran S;Hu C;Capdevila J;COVID-19 Genomics UK (COG-UK) Consortium;Hammers A;Chan AT;Wolf J;Spector TD;Steves CJ;Ourselin S
通讯作者：
Ourselin S
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
DOI：
10.1126/science.abh2644
发表时间：
2021-05-21
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Faria NR;Mellan TA;Whittaker C;Claro IM;Candido DDS;Mishra S;Crispim MAE;Sales FCS;Hawryluk I;McCrone JT;Hulswit RJG;Franco LAM;Ramundo MS;de Jesus JG;Andrade PS;Coletti TM;Ferreira GM;Silva CAM;Manuli ER;Pereira RHM;Peixoto PS;Kraemer MUG;Gaburo N Jr;Camilo CDC;Hoeltgebaum H;Souza WM;Rocha EC;de Souza LM;de Pinho MC;Araujo LJT;Malta FSV;de Lima AB;Silva JDP;Zauli DAG;Ferreira ACS;Schnekenberg RP;Laydon DJ;Walker PGT;Schlüter HM;Dos Santos ALP;Vidal MS;Del Caro VS;Filho RMF;Dos Santos HM;Aguiar RS;Proença-Modena JL;Nelson B;Hay JA;Monod M;Miscouridou X;Coupland H;Sonabend R;Vollmer M;Gandy A;Prete CA Jr;Nascimento VH;Suchard MA;Bowden TA;Pond SLK;Wu CH;Ratmann O;Ferguson NM;Dye C;Loman NJ;Lemey P;Rambaut A;Fraiji NA;Carvalho MDPSS;Pybus OG;Flaxman S;Bhatt S;Sabino EC
通讯作者：
Sabino EC
影响因子：
82.9
作者：
Feng S;Phillips DJ;White T;Sayal H;Aley PK;Bibi S;Dold C;Fuskova M;Gilbert SC;Hirsch I;Humphries HE;Jepson B;Kelly EJ;Plested E;Shoemaker K;Thomas KM;Vekemans J;Villafana TL;Lambe T;Pollard AJ;Voysey M;Oxford COVID Vaccine Trial Group
通讯作者：
Oxford COVID Vaccine Trial Group