Genotypes of Japanese encephalitis virus isolated in three states in Malaysia
Genotypes of Japanese encephalitis virus isolated in three states in Malaysia
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DOI：
10.4269/ajtmh.1997.56.153
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发表时间：
1997-02-01
影响因子：
3.3
通讯作者：
Igarashi, A
中科院分区：
文献类型：
--
作者：
Tsuchie, H;Oda, K;Igarashi, A
对1993~1994年从马来西亚3个不同地区分离的12株乙型脑炎病毒(JEV)分离株的膜前区240个核苷酸进行了序列测定，并与亚洲不同地区分离的JEV进行了比较。这12株马来西亚分离株被分成两种基因类型。1994年从沙捞越分离的4株乙脑病毒和1993年从雪邦雪邦分离的4株乙脑病毒被归类为一个包括马来西亚早期分离株的基因(1968年从沙捞越分离的JE-827和1970年从吉隆坡分离的VvTP/70/22)。1994年分离自泰国北部和柬埔寨的4株乙脑病毒株被归类为另一种毒株。在早些时候的一份报告中，1992年从雪兰莪州沙巴克伯南分离的10株乙型脑炎病毒被归类为最大的基因型别，其中包括从日本、中国和台湾等温带地区分离的毒株。数据表明，至少有三种基因型别的乙脑病毒已在马来西亚流行。
Two hundred forty nucleotides from the pre-membrane gene region of 12 Japanese encephalitis virus (JEV) strains isolated from three different regions of Malaysia from 1993 to 1994 were sequenced and compared with each other and with the JEV strains from different geographic areas in Asia. These 12 Malaysian isolates were classified into two genotypes. The four JEV strains isolated from Sarawak in 1994 and the four JEV strains isolated from Sepang, Selangor in 1993 were classified into one genotype that included earlier isolated strains from Malaysia (JE-827 from Sarawak in 1968 and VvTP/70/22 from Kuala Lumpur in 1970). The four JEV strains from Ipoh, Perak in 1994 were classified into another genotype that included JEV strains isolated from northern Thailand and Cambodia. In an earlier report, 10 JEV strains from Sabak Bernam, Selangor in 1992 were classified into the largest genotype that included strains isolated in temperate regions such as Japan, China, and Taiwan. The data indicate that at least three genotypes of JEV have been circulating in Malaysia.