Onapristone suppresses prolactin production in explant cultures of leiomyoma.
Onapristone suppresses prolactin production in explant cultures of leiomyoma.
复制标题
奥那司酮抑制平滑肌瘤外植体培养物中催乳素的产生。
DOI：
10.1159/000010120
复制
发表时间：
1999
影响因子：
2.1
通讯作者：
Stewart,EA
中科院分区：
文献类型：
--
作者：
Austin,DJ;Nowak,RA;Stewart,EA
目的：评估奥那司酮，一种I型抗孕酮，对泌乳素（PRL）的生产由平滑肌瘤和子宫肌层的外植体培养物的作用。设计：子宫肌层和平滑肌瘤的外植体培养物从3绝经前妇女接受子宫切除术在月经周期的增殖阶段。主要结果测量：PRL分泌测定放射免疫法。结果：PRL分泌减少平滑肌瘤由奥那司酮。对子宫肌层无影响。有没有额外的效果与添加II型抗孕激素米非司酮（RU 486）。结论：PRL的生产是抑制平滑肌瘤，但不是在子宫肌层奥那司酮在体外治疗后。这种抑制可以作为用于治疗平滑肌瘤的药物的临床有效性的标志。
Objective:To assess the action of onapristone, a type I antiprogestin, on prolactin (PRL) production by explant cultures of leiomyoma and myometrium.Design:Explant cultures of myometrium and leiomyomas from 3 premenopausal women undergoing hysterectomy in the proliferative phase of the menstrual cycle.Main Outcome Measures:PRL secretion measured by radioimmunoassay.Results:PRL secretion was decreased in leiomyomas by onapristone. There was no effect in the myometrium. There was no additional effect with the addition of the type II antiprogestin mifepristone (RU 486).Conclusion:PRL production is suppressed in leiomyomas but not in myometrium after treatment with onapristone in vitro. This suppression may serve as a marker for the clinical effectiveness of agents used in the treatment of leiomyomas.