A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
A strongly adhesive hemostatic hydrogel for the repair of arterial and heart bleeds
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DOI：
10.1038/s41467-019-10004-7
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发表时间：
2019-05-14
影响因子：
16.6
通讯作者：
Ouyang, Hongwei
中科院分区：
文献类型：
--
作者：
Hong, Yi;Zhou, Feifei;Ouyang, Hongwei
无法控制的出血是外科手术和重大创伤后的主要问题。现有的止血剂对创伤性动脉和心脏伤口的止血效果不佳，因为它们对湿的和移动的组织的粘附力较弱。在这里，我们设计了一种光反应粘合剂，模仿细胞外基质（ECM）的组成。这种基于生物大分子的基质水凝胶可以在紫外光照射后进行快速胶凝和固定，以粘附和密封出血动脉和心脏壁。这些修复可以承受高达290 mm Hg的血压，明显高于大多数临床环境中的血压（收缩压60-160 mm Hg）。最重要的是，该水凝胶可以阻止来自具有4-5 mm长的切口伤口的猪颈动脉和来自具有6 mm直径的心脏穿透孔的猪心脏的高压出血。经处理的猪在使用该水凝胶进行止血处理后存活，该水凝胶耐受性良好，并且似乎作为创伤性伤口密封剂提供了显著的临床优势。
Uncontrollable bleeding is a major problem in surgical procedures and after major trauma. Existing hemostatic agents poorly control hemorrhaging from traumatic arterial and cardiac wounds because of their weak adhesion to wet and mobile tissues. Here we design a photo reactive adhesive that mimics the extracellular matrix (ECM) composition. This biomacromolecule-based matrix hydrogel can undergo rapid gelling and fixation to adhere and seal bleeding arteries and cardiac walls after UV light irradiation. These repairs can withstand up to 290 mm Hg blood pressure, significantly higher than blood pressures in most clinical settings (systolic BP 60-160 mm Hg). Most importantly, the hydrogel can stop high pressure bleeding from pig carotid arteries with 4-5 mm-long incision wounds and from pig hearts with 6 mm diameter cardiac penetration holes. Treated pigs survived after hemostatic treatments with this hydrogel, which is well-tolerated and appears to offer significant clinical advantage as a traumatic wound sealant.