Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury.
Clinical review: Drug metabolism and nonrenal clearance in acute kidney injury.
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DOI：
10.1186/cc7093
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发表时间：
2008
期刊：
影响因子：
--
通讯作者：
Mueller BA
中科院分区：
文献类型：
--
作者：
Vilay AM;Churchwell MD;Mueller BA
肾脏药物清除率降低是急性肾损伤（阿基）的明显后果。然而，越来越多的证据表明，非肾脏药物清除率也受到影响。来自人类和动物研究的数据表明，肝脏药物代谢和转运蛋白功能是受阿基影响的非肾脏清除的组成部分。急性肾损伤也可能损害形成的代谢物的清除。阿基不仅影响肾功能，这一事实可能对药物给药具有重要意义，不仅是肾脏消除的药物，而且是肝脏清除的药物。针对阿基中药物代谢和清除率变化主题的文献综述表明，非肾脏清除率的变化非常复杂，研究也很少，但它们可能相当常见。目前，我们对阿基如何影响药物代谢和非肾脏清除率的了解有限。然而，根据现有证据，临床医生应认识到，即使是肝脏消除的药物和形成的药物代谢物也可能在阿基期间蓄积，肾脏替代治疗可能影响非肾脏清除以及药物代谢物清除。
Decreased renal drug clearance is an obvious consequence of acute kidney injury (AKI). However, there is growing evidence to suggest that nonrenal drug clearance is also affected. Data derived from human and animal studies suggest that hepatic drug metabolism and transporter function are components of nonrenal clearance affected by AKI. Acute kidney injury may also impair the clearance of formed metabolites. The fact that AKI does not solely influence kidney function may have important implications for drug dosing, not only of renally eliminated drugs but also of those that are hepatically cleared. A review of the literature addressing the topic of drug metabolism and clearance alterations in AKI reveals that changes in nonrenal clearance are highly complicated and poorly studied, but they may be quite common. At present, our understanding of how AKI affects drug metabolism and nonrenal clearance is limited. However, based on the available evidence, clinicians should be cognizant that even hepatically eliminated drugs and formed drug metabolites may accumulate during AKI, and renal replacement therapy may affect nonrenal clearance as well as drug metabolite clearance.
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影响因子：
6.7
作者：
GOLPER, TA;NOONAN, HM;BENNETT, WM
通讯作者：
BENNETT, WM
DOI：
10.1186/cc5949
发表时间：
2007
期刊：
Critical care (London, England)
影响因子：
--
作者：
Bagshaw SM;George C;Bellomo R;ANZICS Database Management Committee
通讯作者：
ANZICS Database Management Committee
影响因子：
5
作者：
Huang, ZH;Murakami, T;Takano, M
通讯作者：
Takano, M
影响因子：
5.9
作者：
GIBSON, TP;DEMETRIADES, JL;BLAND, JA
通讯作者：
BLAND, JA
影响因子：
5.9
作者：
BERMAN, SJ;SUGIHARA, JG;SIEMSEN, AM
通讯作者：
SIEMSEN, AM