Fetal heart rate reactivity differs by women's psychiatric status: An early marker for developmental risk?
Fetal heart rate reactivity differs by women's psychiatric status: An early marker for developmental risk?
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DOI：
10.1097/00004583-200403000-00009
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发表时间：
2004-03-01
影响因子：
13.3
通讯作者：
Fifer, WP
中科院分区：
文献类型：
--
作者：
Monk, C;Sloan, RP;Fifer, WP
Objective: To determine whether there are differences in fetal heart rate (FHR) reactivity associated with women's psychiatric status. Method: In 57 women in their 36th to 38th week of pregnancy (mean age 27 6 years), electrocardiogram, blood pressure (BP), respiration (RSP), and FHR were measured during baseline and a psychological challenge (a Stroop color-word matching task). Subjects underwent the Structured Clinical Interview for DSM-IV(SCID) and completed the Spielberger State-Trait Anxiety Inventory prior to testing. Results: There was a significant main effect of maternal diagnostic group on FHR reactivity during the Stroop task even after controlling for birth weight and women's BP reactivity (F-4.44 = 2.68, p = .04). Fetuses of depressed women had greater heart rate increases compared to fetuses of women with anxiety disorders and those of healthy, low-anxiety women (post hoc comparisons using the Fisher protected least significant difference test; t = 4.12, p < .05; t = 4.72, p < .01, respectively). There was a similar pattern comparing fetuses of healthy, high-anxiety women to the same two groups (t = 3.29, p < .05; t = 3.99, p < .05, respectively). There were no group differences in FHR during a resting baseline period (F-4.52 = 1.2, p = .35). Conclusions: Maternal mood disturbance is associated with alterations in children's physiological reactivity prior to birth.
