MONOCLONAL-ANTIBODIES AGAINST CHONDROITIN SULFATE ISOMERS - THEIR USE AS PROBES FOR INVESTIGATING PROTEOGLYCAN METABOLISM
MONOCLONAL-ANTIBODIES AGAINST CHONDROITIN SULFATE ISOMERS - THEIR USE AS PROBES FOR INVESTIGATING PROTEOGLYCAN METABOLISM
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DOI：
10.1042/bst0180820
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发表时间：
1990-10-01
影响因子：
3.9
通讯作者：
SORRELL, JM
中科院分区：
文献类型：
--
作者：
CATERSON, B;GRIFFIN, J;SORRELL, JM
硫酸软骨素（CS）蛋白聚糖是软骨的主要成分，也是许多其他结缔组织的次要成分。目前的文献表明，软骨蛋白聚糖的聚阴离子CS糖胺聚糖链的主要生物力学功能是有助于维持软骨内的唐南渗透压，参与排除体积效应并有助于组织的粘弹性（综述见[1-31]）。关节软骨蛋白聚糖的生化分析表明，CS的不同异构形式的表达发生在正常生长和发育过程中，并在病理[4-61。CS不同异构体差异表达的目的和功能目前尚不清楚。在本文中，我们提出了一个总结的数据表明，硫酸化模式的CS糖胺聚糖是一个更高度控制，细胞调节
Chondroitin sulphate (CS) proteoglycans are major components of cartilage and lesser constituents of many other connective tissues. Current literature indicates that the major biomechanical functions of the polyanionic CS glycosaminoglycan chains of the cartilage proteoglycans are to contribute towards maintenance of a Donnan osmotic pressure within the cartilage, to participate in excluded volume effects and to contribute to the viscoelastic properties of the tissue (see [1-31 for reviews). Biochemical analysis of articular cartilage proteoglycans indicates that expression of different isomeric forms of CS occurs during normal growth and development, and in pathology [4-61. The purpose and function of the differential expression of the different isomers of CS is at present not known. In this paper we present a summary of data that suggests that sulphation patterns in CS glycosaminoglycans are a more highly controlled, cell-regulated