Catalyst Control of Site Selectivity in the PdII/IV-Catalyzed Direct Arylation of Naphthalene
Catalyst Control of Site Selectivity in the PdII/IV-Catalyzed Direct Arylation of Naphthalene
复制标题
DOI：
10.1021/cs1001543
复制
发表时间：
2011-03-01
期刊：
影响因子：
12.9
通讯作者：
Sanford, Melanie S.
中科院分区：
文献类型：
--
作者：
Hickman, Amanda J.;Sanford, Melanie S.
本文介绍了一种高中心、高化学选择性的Pd催化直接反应的新方法。萘的芳基化。调整结构。那就是。连接的Pd宿命论结果以高产率和>；50：1选择性形成了α-芳基化产物：据我们所知，这是第一次。未活化芳香族底物C-H芳基化反应中催化剂控制的系统评价。初步研究暗示了一种不寻常的机制，涉及到Pd-IV上连续的萘pi配位/金属化。
This letter describes a new method for the highly site and chemoselective Pd-catalyzed direct. arylation of naphthalene. Tuning the structure. of the. ligated Pd fatalist results formation of the alpha-arylated product in high yield and > 50:1 selectivity: to our knowledge, the first. systematic, evaluation of catalyst control in the C-H arylation of an unactivated aromatic sustrate. Preliminary studies implicate an unusual mechanism involving sequential naphthalene pi-coordination/metalation at Pd-IV.