Serum selenium concentrations and hypertension in the US Population.
Serum selenium concentrations and hypertension in the US Population.
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DOI：
10.1161/circoutcomes.108.831552
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发表时间：
2009-07
期刊：
影响因子：
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通讯作者：
Guallar E
中科院分区：
文献类型：
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作者：
Laclaustra M;Navas-Acien A;Stranges S;Ordovas JM;Guallar E
硒是一种具有抗氧化作用的微量营养素，对心血管疾病的预防具有潜在的意义。很少有研究评估硒和高血压之间的联系，结果不一致。我们在美国人群的代表性样本中探讨了血清硒浓度与血压和高血压的关系。对2003-2004年参加国家健康和营养检查调查（NHANES）的2，638名≥40岁的成年人进行了横断面分析。采用电感耦合等离子体动态反应池质谱法测定血清硒。高血压定义为血压≥140/90 mmHg或目前使用抗高血压药物。平均血清硒为137.1 µg/L。比较血清硒最高（≥150 µg/L）和最低（<122 µg/L）五分位数的血压水平，收缩压、舒张压和脉压的多变量校正差异（95%置信区间）分别为4.3（1.3，7.4）、1.6（-0.5，3.7）和2.8（0.8，4.7）mmHg。高血压的相应比值比（95%CI）为1.73（1.18，2.53）。在样条回归模型中，血压水平和高血压患病率随着硒浓度的增加而增加，直至160 µg/L。高血清硒浓度与高血压患病率相关。这些发现要求对美国高硒状态相关的风险和益处进行全面评估。
Selenium is an antioxidant micronutrient with potential interest for cardiovascular disease prevention. Few studies have evaluated the association between selenium and hypertension, with inconsistent findings. We explored the relationship of serum selenium concentrations with blood pressure and hypertension in a representative sample of the US population. Cross-sectional analysis of 2,638 adults ≥40 year old who participated in the National Health and Nutrition Examination Survey (NHANES) 2003–2004. Serum selenium was measured by inductively coupled plasma-dynamic reaction cell-mass spectrometry. Hypertension was defined as blood pressure ≥140/90 mmHg or current use of antihypertensive medication. Mean serum selenium was 137.1 µg/L. The multivariable adjusted differences (95% confidence interval) in blood pressure levels comparing the highest (≥150 µg/L) to the lowest (<122 µg/L) quintile of serum selenium were 4.3 (1.3, 7.4), 1.6 (−0.5, 3.7) and 2.8 (0.8, 4.7) mmHg for systolic, diastolic, and pulse pressure, respectively. The corresponding odds ratio (95% CI) for hypertension was 1.73 (1.18, 2.53). In spline regression models, blood pressure levels and the prevalence of hypertension increased with increasing selenium concentrations up to 160 µg/L. High serum selenium concentrations were associated with higher prevalence of hypertension. These findings call for a thorough evaluation of the risks and benefits associated with high selenium status in the US.