Structural and hormonal alterations in the gastrointestinal tract of parenterally fed rats.
Structural and hormonal alterations in the gastrointestinal tract of parenterally fed rats.
复制标题
肠外喂养大鼠胃肠道的结构和激素变化。
DOI：
10.1016/s0016-5085(75)80232-0
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发表时间：
1975
期刊：
影响因子：
29.4
通讯作者：
Gilbert A. Castro
中科院分区：
文献类型：
--
作者：
Leonard R. Johnson;E. M. Copeland;S. J. Dudrick;L. Lichtenberger;Gilbert A. Castro
本研究探讨了长期不口服食物摄入对大鼠胃肠道结构参数的影响，这些大鼠通过静脉喂养维持营养长达3周。在此期间，他们的体重增加了22%。喂食几乎等量热量的口服食物的对照组进行了假手术，并以与非肠道喂养的对照组相同的方式加以控制。肠外喂养导致胃、小肠和胰腺的氧合腺区域的体重（每100克体重）显著下降。脾脏、睾丸、肾脏和胃胃窦的重量没有改变。在小肠中，肠道外喂养的动物的DNA明显丢失，RNA:DNA比例几乎翻了一番。在没有口服饮食的情况下，胃窦胃泌素水平下降到对照水平的三十分之一。根据这些结果可以得出以下结论：首先，口服摄入和/或食物在胃肠道内的物理存在对于胃肠道某些组织的结构维持是必要的。其次，在某些组织中出现的不成比例的体重减轻显然与通常可以直接从管腔利用的营养物质的缺乏无关。第三，维持正常组织储存的激素胃泌素依赖于口服摄入和胃肠道中存在的食物所提供的刺激。
This study examines the effect of prolonged absence of oral food intake on structural parameters of the gastrointestinal tract in rats maintained nutritionally by intravenous feeding for up to 3 weeks. During this time, their body weights increased by 22%. Controls fed a nearly isocaloric oral diet were sham operated and harnessed in the same manner as their parenterally fed counterparts. Parenteral feeding resulted in a significant decrease in the weights (per 100 g body weight) of the oxyntic gland area of the stomach, small intestine, and pancreas. The weights of the spleen, testes, kidneys, and antral region of the stomach were unaltered. In the small intestine there was a significant loss of DNA and a near doubling of the RNA:DNA ratio in the parenterally fed animals. In the absence of an oral diet antral gastrin levels decreased to one-thirtieth of the control level. The following conclusions are suggested by these results. First, the oral intake and/or physical presence of food within the gastrointestinal tract are necessary for structural maintenance of some tissues of that tract. Second, the disproportionate decrease in weight that occurs in certain tissues is apparently unrelated to the absence of nutrients which might normally be utilized directly from the lumen. Third, maintenance of normal tissue stores of the hormone, gastrin, is dependent on stimuli provided by oral ingestion and the presence of food in the gastrointestinal tract.