Antibody directed enzyme prodrug therapy (ADEPT) and related approaches for anticancer therapy.
Antibody directed enzyme prodrug therapy (ADEPT) and related approaches for anticancer therapy.
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抗体导向酶前药疗法（ADEPT）和相关的抗癌治疗方法。
DOI：
10.2174/1389557013406747
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
M. Jung
中科院分区：
文献类型：
--
作者：
M. Jung
在抗体导向的酶前药疗法（ADEPT）中，抗体结合的酶靶向肿瘤细胞。这允许在肿瘤部位将无毒前药选择性活化为细胞毒性剂用于癌症治疗。位点选择性前药活化导致在远端组织中的副作用减少。本文综述了ADEPT的化学观点和最新进展。
In antibody directed enzyme prodrug therapy (ADEPT) an antibody bound enzyme is targeted to tumor cells. This allows for selective activation of a nontoxic prodrug to a cytotoxic agent at the tumor site for cancer therapy. Site-selective prodrug activation results in reduced side effects in remote tissue. This article reviews ADEPT with emphasis on the chemical viewpoint and recent developments.