The promise of induced pluripotent stem cells in research and therapy.

The promise of induced pluripotent stem cells in research and therapy.
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DOI:
10.1038/nature10761
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发表时间:
2012-01-18
期刊:
影响因子:
64.8
通讯作者:
Daley, George Q.
Daley, George Q.
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Robinton, Daisy A.;Daley, George Q.

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The field of stem-cell biology has been catapulted forward by the startling development of reprogramming technology. The ability to restore pluripotency to somatic cells through the ectopic co-expression of reprogramming factors has created powerful new opportunities for modelling human diseases and offers hope for personalized regenerative cell therapies. While the field is racing ahead, some researchers are pausing to evaluate whether induced pluripotent stem cells are indeed the true equivalents of embryonic stem cells and whether subtle differences between these cells might affect their research applications and therapeutic potential.
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