Impact of hyperbilirubinemia associated acute kidney injury on chronic kidney disease after aortic arch surgery: a retrospective study with follow-up of 1-year.
Impact of hyperbilirubinemia associated acute kidney injury on chronic kidney disease after aortic arch surgery: a retrospective study with follow-up of 1-year.
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高胆红素血症相关急性肾损伤对主动脉弓术后慢性肾脏病的影响：一项为期一年随访的回顾性研究
DOI：
10.1186/s13019-022-01992-7
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发表时间：
2022-09-29
影响因子：
1.6
通讯作者：
Yuan, Li
中科院分区：
文献类型：
--
作者：
Lyu, Lin;Song, Haicheng;Gao, Guodong;Dong, He;Liao, Pingping;Shen, Ziying;Liu, Hui;Chu, Haichen;Yuan, Li
背景高胆红素血症（HB）是主动脉弓手术的严重并发症，与急性肾损伤（阿基）密切相关。HB和慢性肾脏病（CKD）之间的关系尚不清楚。本研究的目的是调查HB相关阿基对主动脉弓手术后CKD的影响。方法我们回顾了2016年至2020年在我院接受主动脉弓手术的284例患者。阿基定义为术后前7天内sCr较基线值增加50%。HB定义为总胆红素> 51.3 μmol/L。根据阿基和HB将患者分为3组：HB相关阿基（HB AKI）组（阿基患者在术后前7天内发生HB）;阿基无HB组和非AKI组。Kaplan-Meier分析显示，HB-AKI（32.6%）的1年累积CKD发生率最高，高于无HB的阿基（17.8%）和非AKI（7.4%，对数秩检验，p < 0.001），HB组的CKD发生率高于非HB组（26.7% vs. 13.9%，对数秩检验，p = 0.015）。术前sCr（HR 1.010，95% CI 1.004-1.016，p = 0.001），不伴HB的阿基（HR 2.887，95% CI 1.133-7.354，p = 0.026）和HB-AKI（HR 4.490，95%CI 1.59-12.933，p = 0.005）与CKD相关。结论主动脉弓手术后，HB相关阿基患者比无HB的阿基患者发生CKD的几率更高。
BackgroundHyperbilirubinemia (HB) is a serious complication in aortic arch surgery, which is associated with acute kidney injury (AKI). The association between HB and chronic kidney disease (CKD) is unknown. The aim of this study was to investigate the impact of HB associated AKI on CKD after aortic arch surgery.MethodsWe reviewed 284 patients who underwent aortic arch surgery from 2016 to 2020 in our hospital. AKI was defined as a 50% increase in sCr from baseline value within the first 7 postoperative days. HB was defined as total bilirubin > 51.3 μmol/L. Patients were divided into 3 groups based on AKI and HB: HB associated AKI (HB-AKI) group (AKI patients suffered HB within the first 7 postoperative days); AKI without HB group and Non-AKI group.ResultsFollow-up for 204 patients ranged from 3 to 12 months. Kaplan–Meier analysis showed that the 1-year cumulative incidence of CKD was highest in HB-AKI (32.6%) than AKI without HB (17.8%) and Non-AKI (7.4%, log-rank test, p < 0.001), and the incidence of CKD was higher in HB group than that in Non-HB group (26.7% vs. 13.9%, log-rank test, p = 0.015). Preoperative sCr (HR 1.010, 95% CI 1.004–1.016, p = 0.001), AKI without HB (HR 2.887, 95% CI 1.133–7.354, p = 0.026) and HB-AKI (HR 4.490, 95% CI 1.59–12.933, p = 0.005) were associated with CKD during 1-year follow-up.ConclusionsPatients suffering HB associated AKI were at more increased odds of CKD than patients suffering AKI without HB after aortic arch surgery.
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影响因子：
2.5
作者：
Yuan, Li;Liao, Ping-Ping;Lyu, Lin
通讯作者：
Lyu, Lin
影响因子：
6.1
作者：
Haase, Michael;Bellomo, Rinaldo;Haase-Fielitz, Anja
通讯作者：
Haase-Fielitz, Anja
影响因子：
9.8
作者：
Sakoh, Teppei;Nakayama, Masaru;Kitazono, Takanari
通讯作者：
Kitazono, Takanari
影响因子：
6.8
作者：
Targher, Giovanni;Bosworth, Cortney;Chonchol, Michel
通讯作者：
Chonchol, Michel
DOI：
10.1016/j.jamcollsurg.2007.11.021
发表时间：
2008-04-01
影响因子：
5.2
作者：
Kraev, Alexander I.;Torosoff, Mikhail T.;Perez-Tamayo, R. Anthony
通讯作者：
Perez-Tamayo, R. Anthony