Superior cerebellar peduncle atrophy of progressive supranuclear palsy on phase difference enhanced imaging: a comparison with Parkinson's disease
Superior cerebellar peduncle atrophy of progressive supranuclear palsy on phase difference enhanced imaging: a comparison with Parkinson's disease
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进行性核上性麻痹的小脑上脚萎缩的相位差增强成像：与帕金森病的比较
DOI：
10.1007/s00234-023-03119-8
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发表时间：
2023
期刊：
影响因子：
2.8
通讯作者：
Yukunori Korogi
中科院分区：
文献类型：
--
作者：
Mari Miyata;Shingo Kakeda;Tetsuya Yoneda;Satoru Ide;Kazumasa Okada;Hiroaki Adachi;Yukunori Korogi
目的相位差增强（PADRE）成像可增强髓鞘密度，显示上级小脑脚（SCP）。我们的目的是确定SCP萎缩是可区分的PADRE成像，并评估其诊断性能与以前的MRI进行性核上性麻痹（PSP）findings.MethodsTwo revisers测量的SCP宽度PADRE在20 PSP和31帕金森病（PD）患者。在3D-T1 WI上测量SCP和小脑中脚（MCP）宽度、脑桥和中脑面积，计算脑桥面积与中脑面积的比值、MCP/SCP比值和磁共振帕金森综合征指数（MRPI）。我们使用Steel-Dwass检验比较PSP、PD和HS，并使用受试者工作特征曲线（ROC）分析评估从PD诊断PSP的敏感性和特异性。结果在放射科医师1中，PSP的PADRE SCP（1.1 ± 0.3 mm）明显小于PD的SCP（2.4 ± 0.4 mm）（P< 0.001），曲线下面积（AUC）为0.97。以1.75 mm为界值，PSP与PD的诊断敏感性和特异性分别为93.5%和100%。SCP在PADRE上的AUC值明显高于3D-T1 WI参数（SCP、MCP、脑桥面积、MCP/SCP比值和MRPI）。
PurposePhase difference enhanced (PADRE) imaging can enhance myelin density and delineate the superior cerebellar peduncle (SCP). We aimed to determine if SCP atrophy was distinguishable on PADRE imaging and evaluate its diagnostic performance compared with previous MRI progressive supranuclear palsy (PSP) findings.MethodsTwo reviewers measured the SCP widths on PADRE in 20 PSP and 31 Parkinson’s disease (PD) patients. The SCP and middle cerebellar peduncle (MCP) widths and the pons and midbrain areas were measured on 3D-T1WI, and the ratio of the area of the pons to the area of the midbrain, the MCP/SCP ratio, and the magnetic resonance parkinsonism index (MRPI) were calculated. We used the Steel–Dwass test to compare PSP, PD, and HS, and receiver operating characteristic curve (ROC) analyses to assess the sensitivity and specificity for diagnosing PSP from PD. A comparison of ROC curves was performed between the SCP on PADRE and these 3D-T1WI parameters.ResultsIn radiologist 1, the SCP on PADRE in PSP (1.1 ± 0.3 mm) was significantly smaller than those in PD (2.4 ± 0.4 mm) (P< 0.001); the area under the curve (AUC) was 0.97. At a 1.75-mm cutoff value, the diagnostic sensitivity and specificity for differentiating PSP from PD were 93.5% and 100%, respectively. The AUC of the SCP on PADRE was significantly higher than the 3D-T1WI parameters (the SCP, MCP, pons area, MCP/SCP ratio, and MRPI).ConclusionAssessing SCP with PADRE imaging may yield high diagnostic accuracy for discriminating PSP from PD.