Evaluation of the bactericidal activity of povidone-iodine and commercially available gargle preparations
Evaluation of the bactericidal activity of povidone-iodine and commercially available gargle preparations
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DOI：
10.1159/000057723
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发表时间：
2002-01-01
期刊：
影响因子：
3.4
通讯作者：
Nakagawa, Y
中科院分区：
文献类型：
--
作者：
Shiraishi, T;Nakagawa, Y
目的：鼓励漱口对控制机会性感染和社区获得性感染具有重要意义。在医院，聚维酮碘（PVP-I）漱口液经常使用。不过，现时在社区的药房，有多种含不同成分的漱口水出售。有鉴于此，我们进行了一项研究，将PVP-I漱口液与其他市售漱口液的杀菌活性进行比较。另外，我们还通过问卷的形式询问了使用后的感觉。在我市的中学，我们调查了鼓励使用PVP-I漱口液是否对因感冒和流感而缺课的影响。研究方法：以3株革兰氏阳性菌和4株革兰氏阴性菌为供试菌，采用接触试验法，比较PVP-Ⅰ、葡萄糖酸氯己定（CHG）和氯化十六烷基吡啶（CPC）漱口液的体外杀菌活性。在体内，每组6名受试者，测定漱口后口腔细菌计数与漱口前基线计数相比的减少率，并在使用的3种漱口剂之间进行比较。并进行问卷调查，比较3种含漱剂使用后的感觉。通过比较一所使用PVP-I漱口液的中学和其他未使用PVP-I漱口液的中学，确定鼓励使用PVP-I漱口液是否会改变因普通感冒和流感而导致的缺勤率。结果：（1）PVP-I作用30 s后，所有试验菌株均被杀灭。(2)漱口后即刻细菌计数的平均减少率分别为PVP-I 99.4%、CHG 59.7%和CPC 97.0%。(3)问卷调查结果显示，在所有受试漱口液中，PVP-I漱口液在味道、漱口后感觉和气味方面的评价最高。(4)在鼓励使用PVP-I漱口液的中学，与使用另一种漱口液的中学相比，因普通感冒和流感而缺席的比例显着降低。结论：在3种含漱液中，PVP-I的杀菌率最高，口腔菌数减少率最高。鼓励使用PVP-I漱口液有助于降低因普通感冒和流感而缺席的比率，表明鼓励使用PVP-I漱口对预防普通感冒和流感是有用的。版权所有（C）2002 S. Karger AG，巴塞尔。
Objective: Encouragement of gargling is important for the control of opportunistic and community-acquired infections. In hospitals, a povidone-iodine (PVP-I) gargle is used frequently. However, at pharmacies in the community a variety of gargles containing various ingredients are now available. In view of this, we conducted a study to compare the bactericidal activities of a PVP-I gargle with those of other commercially available gargles. In addition, we asked about the feeling after use by questionnaire. At middle schools in our city, we investigated whether the encouragement to use the PVP-I gargle had an effect on the absence rate from school due to common cold and influenza. Methods: In vitro, using 3 strains of gram-positive and 4 strains of gram-negative bacteria as the test strains, the bactericidal activities of the PVP-I, chlorhexidine gluconate (CHG) and cetylpiridium chloride gargles (CPC) were compared by the contact test method. In vivo, with subjects in groups of 6 each, the reduction rate in the oral bacterial count after gargling as compared to the baseline count before gargling was determined and compared among the 3 gargling agents used. In addition, a questionnaire study was conducted to compare the feeling after use of the 3 gargling agents. Whether the absence rate due to common cold and influenza changed by encouraging the use of the PVP-I gargle was determined by comparing a middle school where the PVP-I gargle was used and other middle schools where it was not. Results: (1) PVP-I killed all the test strains after 30 s of exposure. (2) The mean reduction rate in bacterial count immediately after gargling was 99.4% for PVP-I, 59.7% for CHG and 97.0% for CPC. (3) Findings of the questionnaire study revealed that the PVP-I gargle was evaluated highest in terms of taste, feeling after gargling and odor among all the gargles tested. (4) At the middle school where the use of the PVP-I gargle was encouraged, the absence rate due to common cold and influenza was significantly lower as compared to those at middle schools where another gargle was used. Conclusion: Of the 3 gargles tested, PVP-I showed the highest bactericidal rate and the highest reduction rate in oral bacterial count. Encouragement of the use of the PVP-I gargle contributed to the decrease in absence rates due to common cold and influenza, indicating that encouragement of gargling with PVP-I is useful for the prevention of common cold and influenza. Copyright (C) 2002 S. Karger AG, Basel.