Sex differences in the association of metabolic syndrome with low back pain among middle-aged Japanese adults: a large-scale cross-sectional study
Sex differences in the association of metabolic syndrome with low back pain among middle-aged Japanese adults: a large-scale cross-sectional study
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DOI：
10.1186/s13293-019-0249-3
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发表时间：
2019-07-05
影响因子：
7.9
通讯作者：
Kokaze, Akatsuki
中科院分区：
文献类型：
--
作者：
Yoshimoto, Takahiko;Ochiai, Hirotaka;Kokaze, Akatsuki
背景尽管最近的一些研究表明代谢综合征（MetS）与肌肉骨骼疾病之间存在关联，但对MetS与下腰痛（LBP）的关联知之甚少。本研究旨在探讨性别差异的关联代谢综合征和代谢综合征的组成部分与LBP之间的中年日本individuals.MethodsStudy受试者45，192成年人（30，695名男性，14，497名女性）年龄在40- 64岁谁进行了年度健康检查，从2013年4月至2014年3月。根据日本代谢综合征标准审查委员会的标准，代谢综合征定义为腹部肥胖加上血脂异常、高血压或高血糖中的至少两种。采用自填式问卷收集LBP和健康相关生活方式的信息。结果经年龄和生活方式因素调整后，男性代谢综合征与LBP的OR值为1.15（95%CI 0.95-1.40），女性为2.16（95%CI 1.32-3.53）。与无腹部肥胖的受试者相比，男性中腹部肥胖的存在显著增加了LBP的OR（仅腹部肥胖：OR 1.34，95% CI 1.02-1.76;腹部肥胖+一个组分：OR 1.24，95% CI 1.01-1.52;腹部肥胖+两个或多个组分：OR 1.26，95% CI 1.02-1.55）。在女性中，将MetS的其他成分加入腹部肥胖显著增加了LBP的OR（仅腹型肥胖：OR 1.70，95% CI 0.94-3.08;腹型肥胖+一个组分：OR 1.66，95% CI 1.06-2.60;腹型肥胖+两个或多个组分：OR 2.30，95%CI 1.41-3.78）。结论这项大规模的横断面研究表明，MetS与LBP仅在女性中显著相关，并且MetS组分的聚集与LBP之间的关联存在性别差异。可能需要考虑按性别对MetS成分进行聚集以预防LBP，尽管还需要进一步的前瞻性研究来阐明因果关系。
BackgroundAlthough some recent studies have indicated an association between metabolic syndrome (MetS) and musculoskeletal disease, little is known about the association of MetS with low back pain (LBP). The present study aimed to investigate sex differences in the association of MetS and the clustering of MetS components with LBP among middle-aged Japanese individuals.MethodsStudy subjects were 45,192 adults (30,695 men, 14,497 women) aged 40-64years who underwent annual health checkups conducted from April 2013 to March 2014. MetS was defined according to the criteria of the Examination Committee of Criteria for MetS in Japan as abdominal obesity plus at least two of dyslipidemia, high blood pressure, or high blood glucose. Information on LBP and health-related lifestyles were collected using a self-administered questionnaire. Logistic regression modeling was used to calculate the odds ratio (OR) and 95% confidence interval (CI) for LBP.ResultsAfter adjusting for age and lifestyle factors, the OR of MetS for LBP was 1.15 (95% CI 0.95-1.40) in men and 2.16 (95% CI 1.32-3.53) in women. Compared to subjects without abdominal obesity, the presence of abdominal obesity significantly increased the OR for LBP among men (abdominal obesity only: OR 1.34, 95% CI 1.02-1.76; abdominal obesity plus one component: OR 1.24, 95% CI 1.01-1.52; abdominal obesity plus two or more components: OR 1.26, 95% CI 1.02-1.55). Among women, adding other components of MetS to abdominal obesity significantly increased ORs for LBP (abdominal obesity only: OR 1.70, 95% CI 0.94-3.08; abdominal obesity plus one component: OR 1.66, 95% CI 1.06-2.60; abdominal obesity plus two or more components: OR 2.30, 95% CI 1.41-3.78).ConclusionsThis large-scale cross-sectional study indicated that MetS was significantly associated with LBP among women only and that a sex-difference existed in the association between the clustering of MetS components and LBP. Clustering of MetS components by sex may need to be considered for the prevention of LBP, although further prospective studies are needed to clarify the causality.