Inflammation and aging: Can endocannabinoids help?
Inflammation and aging: Can endocannabinoids help?
复制标题
DOI：
10.1016/j.biopha.2008.02.004
复制
发表时间：
2008-04-01
影响因子：
7.5
通讯作者：
Wenk, Gary L.
中科院分区：
文献类型：
--
作者：
Marchalant, Yannick;Brothers, Holly M.;Wenk, Gary L.
由于大脑中的神经退行性过程，衰老往往导致认知能力下降。随着人们寿命的延长，人们越来越关注与长期的、缓慢衰弱的疾病有关的问题，例如阿尔茨海默氏病，目前尚未找到治愈方法。最近，神经炎症的作用引起了人们的关注，因为它起病缓慢，慢性性质及其在许多不同神经退行性疾病发展中的可能作用。在未来，慢性神经炎症的治疗可能有助于对抗神经退行性疾病的各个方面。我们最近的研究集中在内源性大麻素系统对神经炎症表达的独特作用。操纵内源性大麻素系统在大脑中结合现有的治疗阿尔茨海默病的基础将在这篇评论中讨论。(c)2008年，Elsevier Masson SAS。All rights reserved.
Aging often leads to cognitive decline due to neurodegenerative process in the brain. As people live longer, there exists a growing concern linked to long-term, slowly debilitating diseases, such as Alzheimer's disease for which a cure has not yet been found. Recently, the role of neuroinflammation has attracted attention due to its slow onset, chronic nature and its possible role in the development of many different neurodegenerative diseases. In the future, treatment of chronic neuroinflammation may help counteract aspects of neurodegenerative disease. Our recent studies have focused upon the endocannabinoid system for its unique effects on the expression of neuroinflammation. The basis for the manipulation of the endocannabinoid system in the brain in combination with existing treatments for Alzheimer's disease will be discussed in this review. (c) 2008 Elsevier Masson SAS. All rights reserved.