Quality of life in long-term cervical cancer survivors: A population-based study
Quality of life in long-term cervical cancer survivors: A population-based study
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DOI：
10.1016/j.ygyno.2012.12.033
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发表时间：
2013-04-01
影响因子：
4.7
通讯作者：
Joly, Florence
中科院分区：
文献类型：
--
作者：
Le Borgne, Gwenael;Mercier, Mariette;Joly, Florence
目标.评估宫颈癌幸存者（CCS）诊断后5年、10年和15年的长期生活质量（QOL）。在一项基于人群的横断面研究中，从法国3个肿瘤登记处随机选择1990年、1995年或2000年诊断的CCS。健康对照组是从选民名册中随机挑选的，按年龄组和居住地区分层。使用了5份QOL问卷（SF-36、EORTC QLQ-C30、宫颈癌特定模块（EORTC QLQ-CX 24）、MFI疲劳问卷、焦虑STAI）和生活状况问卷。采用方差分析比较不同诊断时期（5年、10年和15年）的生存者与对照组的生活质量评分，并根据治疗方式调整社会人口学数据。共有173名局部CCS（42%单独手术治疗，58%联合治疗）和594名对照参与了研究。与对照组相比，除了15年生存者的心理情感领域受损外，CCS表达了总体相似的良好生活质量（p
Objectives. To assess long-term quality of life (QOL) in cervical cancer survivors (CCSs), 5, 10, and 15 years after diagnosis.Methods. In a cross-sectional population-based study, CCSs diagnosed in 1990, 1995, or 2000 were randomly selected from 3 tumor registries in France. Healthy controls were randomly selected from electoral rolls, stratifying on age group and residence area. Five QOL questionnaires (SF-36, EORTC QLQ-C30, the cervical cancer-specific module (EORTC QLQ-CX24), the MFI fatigue questionnaire, the STAI for anxiety) and a life condition questionnaire were used. Analysis of variance was used to compare QOL scores of survivors by period of diagnosis (5, 10, and 15 years) with those of controls and according to treatment modality, adjusted for socio-demographic data.Results. A total of 173 localized CCSs (42% treated with surgery alone and 58% with a combination of treatments) and 594 controls participated in the study. Compared with controls, CCSs expressed globally similar good QOL, except for impaired psychoemotional domains in 15-year survivors (p