Prednisolone disposition in cushingoid and noncushingoid kidney transplant patients.
Prednisolone disposition in cushingoid and noncushingoid kidney transplant patients.
复制标题
库欣样和非库欣样肾移植患者的泼尼松龙处置。
DOI：
10.1210/jcem-51-3-561
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
W. Amend
中科院分区：
文献类型：
--
作者：
J. Gambertoglio;Flavio Vincenti;Feduska Nj;J. Birnbaum;Oscar Salvatierra;W. Amend
Little information is available on the disposition of prednisolone in kidney transplant patients and whether correlations exist between the pharmacokinetics and therapeutic or toxic effects of this drug. The present study was designed to determine the pharmacokinetics of prednisolone in six noncushingoid and six cushingoid transplant recipients. The elimination half-lives were not significantly different in the noncushingoid and cushingoid patients (2.3 vs. 3.3 h). However, other pharmacokinetic parameters were significantly lower in the cushingoid group: plasma clearance (147 vs. 82 ml/min) and volume of distribution (32 vs. 20 liters). In addition, the availability of prednisolone after oral prednisone administration was considerably variable (overall range, 27-108%) and was not significantly different between the two groups. Thus, in kidney transplant patients it appears that the plasma clearance and volume of distribution of prednisolone may distinguish between noncushingoid and cushingoid patients.
