On the oxygenation‐dependent 129Xe T 1 in blood
On the oxygenation‐dependent 129Xe T 1 in blood
复制标题
血液中氧合依赖性 129Xe T 1
作者：
J. Wolber;A. Cherubini;M. Leach;A. Bifone
血液中超极化129的自旋晶格弛豫时间T1对血氧敏感。特别是，已经表明，129 μ T1在静脉血中比在动脉血中短。我们已经研究了超极化129氚溶解在人体血液中的T1作为血氧水平的函数，sO2，在生理氧合范围内。结果表明，129 Ω弛豫速率T_{1}^{-1}$随sO_2的变化呈非线性关系。这一发现表明，氙与脱氧血红蛋白的顺磁性血红素基团的直接相互作用不是血液中129氙的主要氧合依赖性弛豫机制。这些结果证实了129 NT 1的氧合依赖性是由氧结合诱导的血红蛋白构象变化决定的。版权所有© 2000约翰威利父子有限公司。
The spin‐lattice relaxation time, T1, of hyperpolarized 129Xe in blood is sensitive to blood oxygenation. In particular, it has been shown that 129Xe T1 is shorter in venous blood than in arterial blood. We have studied the T1 of hyperpolarized 129Xe dissolved in human blood as a function of blood oxygenation level, sO2, in the physiological oxygenation range. We show that the 129Xe relaxation rate, $T_{1}^{-1}$, varies in a nonlinear fashion as a function of sO2. This finding suggests that direct interaction of xenon with the paramagnetic heme group of deoxyhemoglobin is not the dominant oxygenation‐dependent relaxation mechanism for 129Xe in blood. These results corroborate the idea that the oxygenation‐dependence of 129Xe T1 is determined by conformational changes of hemoglobin induced by oxygen binding. Copyright © 2000 John Wiley & Sons, Ltd.
影响因子：
2.2
作者：
Albert, MS;Kacher, DF;Jolesz, FA
通讯作者：
Jolesz, FA