The µ-opioid receptor: an electrophysiologist's perspective from the sharp end.
The µ-opioid receptor: an electrophysiologist's perspective from the sharp end.
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µ-阿片受体：电生理学家从尖端的视角。
DOI：
10.1111/bph.12633
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发表时间：
2015
影响因子：
7.3
通讯作者：
Henderson G
中科院分区：
文献类型：
--
作者：
Henderson G
吗啡是典型的阿片类镇痛药，主要通过激活中枢和周围神经系统神经元中表达的μ阿片受体来产生其行为效应。这一视角提供了过去 40 年来电生理记录技术的使用如何帮助揭示吗啡和其他阿片类药物急性和慢性激活 μ-阿片受体改变神经元功能的分子机制的历史观点。 链接文章本文是“阿片类药物：功能选择性的新途径”主题部分的一部分。要查看本节中的其他文章，请访问 http://dx.doi.org/10.1111/bph.2015.172.issue-2
Morphine, the prototypical opioid analgesic drug, produces its behavioural effects primarily through activation of μ‐opioid receptors expressed in neurones of the central and peripheral nervous systems. This perspective provides a historical view of how, over the past 40 years, the use of electrophysiological recording techniques has helped to reveal the molecular mechanisms by which acute and chronic activation of μ‐opioid receptors by morphine and other opioid drugs modify neuronal function.Linked ArticlesThis article is part of a themed section on Opioids: New Pathways to Functional Selectivity. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue-2