Anti-Müllerian hormone gene polymorphism is associated with androgen levels in Chinese polycystic ovary syndrome patients with insulin resistance
Anti-Müllerian hormone gene polymorphism is associated with androgen levels in Chinese polycystic ovary syndrome patients with insulin resistance
复制标题
抗苗勒氏管激素基因多态性与中国多囊卵巢综合征胰岛素抵抗患者雄激素水平的相关性
DOI：
10.1007/s10815-015-0641-9
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发表时间：
2016
影响因子：
3.1
通讯作者：
B. Guan
中科院分区：
文献类型：
--
作者：
M. Zheng;Yan Li;R. Hu;Fei;Xiao;B. Guan
目的探讨抗苗勒管激素（AMH）及其特异性受体抗苗勒管激素II型受体（AMHRII）基因多态性与多囊卵巢综合征（PCOS）激素紊乱及表型的关系。分析AMH和AMHRII两种基因多态性以及参与者的临床特征，如体重指数（BMI）、血清促黄体生成素（LH）、雌二醇（E2）水平、总睾酮水平（T）和胰岛素抵抗稳态模型评估（HOMA-IR）。采用多因素降维方法分析AMH和AMHRII基因的基因-基因相互作用。结果IR-PCOS女性和对照组AMH基因多态性存在显著差异。AMH和AMHR Ⅱ基因多态性在非IR PCOS组和正常对照组间差异无统计学意义。IR-PCOS患者AMH基因型与血清LH水平密切相关（P = 0.000），睾酮（P = 0.000）和HOMA-IR（P = 0.038），而在非IR-PCOS组和正常组中，AMH和AMHRII基因对AMH和AMHRII基因的表达无影响。结论AMH信号通路中AMH基因型的多样性可能与PCOS的易感性和表型有关，胰岛素抵抗
PurposeThe objective of the study was to investigate whether genetic polymorphisms of the anti-Müllerian hormone (AMH) and its specific receptor anti-Müllerian hormone type II receptor (AMHRII) were associated with the hormone disorder and phenotype of polycystic ovary syndrome (PCOS).MethodsThis case-control study included 141 PCOS patients and 123 normal women. Two polymorphisms of AMH and AMHRII and the clinical characteristics of participants such as body mass index (BMI), serum luteinizing hormone (LH), estradiol levels (E2), total testosterone levels (T), and homeostasis model assessment of insulin resistance (HOMA-IR) were analyzed with the case-control sample. Gene–gene interactions of AMH and AMHRII genes were analyzed based multifactor-dimensionality reduction method.ResultsA significant difference of AMH gene polymorphisms were observed in IR-PCOS women and controls. The AMH and AMHRII gene polymorphisms were not found a significant difference in non-IR-PCOS and normal groups. To IR-PCOS women, genotypes of AMH were closely related to the serum levels of LH (P = 0.000), testosterone (P = 0.000) and HOMA-IR (P = 0.038), while in the non-IR-PCOS and normal groups, no relationship was found. No impact of AMH and AMHRII gene–gene interactions was demonstrated.ConclusionsOur research suggests that the diversity of AMH genotypes in the AMH signal pathway may be connected with the susceptibility and phenotype of PCOS with insulin resistance.