Clinical pharmacokinetics of epirubicin: the importance of liver biochemistry tests.
Clinical pharmacokinetics of epirubicin: the importance of liver biochemistry tests.
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表柔比星的临床药代动力学：肝脏生化测试的重要性。
DOI：
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发表时间：
1992
影响因子：
8.8
通讯作者：
Marcia J. S. Richards
中科院分区：
文献类型：
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作者：
CJ Twelves;Nathan B Dobbs;Y. Michael;LA Summers;W. Gregory;PG Harper;RD Rubens;Marcia J. S. Richards
研究了52例晚期乳腺癌妇女的肝脏生化检查对表柔比星药代动力学的影响，其中27例经放射学证实有肝转移。患者接受表阿霉素12.5 ~ 120mg m-2静脉滴注。第一个疗程后用高效液相色谱法测定表柔比星水平。将22例AST和胆红素均正常的患者与30例AST +/-胆红素升高的患者的表阿霉素消除（以清除率（剂量/AUC）表示）进行比较。无论胆红素正常（22例）还是升高（8例），AST升高患者的表柔比星清除率均显著降低。在30例AST +/-胆红素升高的患者中，表阿霉素清除率与AST水平密切相关（r = -0.72），但与血清胆红素、碱性磷酸酶、白蛋白或肌酐水平无关。通过多元回归分析，AST是预测表阿霉素清除率的唯一生化变量（r2 = 0.47, P = 0.0006）。我们的结论是，升高的血清谷丙转氨酶是一个更敏感和可靠的测量异常表阿霉素药代动力学比增加胆红素。这些发现对肝生化异常患者的蒽环类药物治疗具有启示意义。
The influence of liver biochemistry tests on epirubicin pharmacokinetics has been investigated in 52 women with advanced breast cancer, 27 of whom had radiologically proven liver metastases. Patients received epirubicin 12.5-120 mg m-2 given as an i.v. bolus. Epirubicin levels were measured by HPLC following the first cycle of treatment. Epirubicin elimination, expressed as clearance (dose/AUC), in the 22 patients with normal AST and bilirubin was compared with that of 30 patients with a raised AST +/- raised bilirubin. Epirubicin clearance was significantly reduced in the patients with a raised AST, whether their serum bilirubin was normal (22 patients) or elevated (eight patients). In the 30 patients with a raised AST +/- raised bilirubin, epirubicin clearance correlated strongly with the level of AST (r = -0.72) but not with serum bilirubin, alkaline phosphatase, albumin or creatinine. Using a multiple regression analysis, AST was the only one of these biochemical variables predictive of epirubicin clearance (r2 = 0.47, P = 0.0006). We conclude that a raised serum AST is a more sensitive and reliable measure of abnormal epirubicin pharmacokinetics than increased bilirubin. These findings have implications for anthracycline treatment in patients with abnormal liver biochemistry.
甲磺酸艾日布林在肾功能正常和受损的癌症患者中的药代动力学。
影响因子：
3
作者：
Tan,AntoinetteR;Sarantopoulos,John;Lee,Lucy;Reyderman,Larisa;He,Yi;Olivo,Martin;Goel,Sanjay
通讯作者：
Goel,Sanjay