The DNA polymerase alpha-primase complex: multiple functions and interactions.
The DNA polymerase alpha-primase complex: multiple functions and interactions.
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DOI：
10.1100/tsw.2003.05
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发表时间：
2003-03-17
影响因子：
--
通讯作者：
Plevani P
中科院分区：
文献类型：
--
作者：
Muzi-Falconi M;Giannattasio M;Foiani M;Plevani P
DNA聚合酶_ （pol _）在真核生物DNA聚合酶家族中占有特殊的地位。事实上，pol _与DNA引物酶结合形成一个四亚基复合物，因此，它是唯一能够开始DNA合成的酶。由于这种特性，DNA聚合酶-引物酶复合体（pol-prim）的主要作用是在染色体起点的DNA复制起始和复制叉后链上的冈崎片段的不连续合成中。然而，pol-prim似乎在其他复杂的细胞过程中起着额外的作用，例如对DNA损伤的反应，端粒维护和高阶染色质组装的表观遗传控制。
DNA polymerase _ (pol _) holds a special position among the growing family of eukaryotic DNA polymerases. In fact, pol _ is associated with DNA primase to form a four subunit complex and, as a consequence, is the only enzyme able to start DNA synthesis de novo. Because of this peculiarity the major role of the DNA polymerase _-primase complex (pol-prim) is in the initiation of DNA replication at chromosomal origins and in the discontinuous synthesis of Okazaki fragments on the lagging strand of the replication fork. However, pol-prim seems to play additional roles in other complex cellular processes, such as the response to DNA damage, telomere maintenance, and the epigenetic control of higher order chromatin assembly.