Effects of treated and untreated depressive symptoms on highly active antiretroviral therapy use in a US multi-site cohort of HIV-positive women
Effects of treated and untreated depressive symptoms on highly active antiretroviral therapy use in a US multi-site cohort of HIV-positive women
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DOI：
10.1080/09540120500159284
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发表时间：
2006-02-01
影响因子：
1.7
通讯作者：
Young, M
中科院分区：
文献类型：
--
作者：
Cook, JA;Grey, D;Young, M
本研究探讨了治疗和未治疗的抑郁症状对使用高活性抗逆转录病毒治疗（HAART）的可能性的影响，在多地点的hiv感染妇女中筛查出可能的抑郁症阳性。在一项前瞻性队列研究中，从1996年到2002年每半年收集一次数据。在控制临床指标（CD4计数、病毒载量）、人口统计学特征（种族/民族、收入）和行为因素（最近吸食快克、可卡因或海洛因）的情况下，使用随机效应回归分析来估计心理健康治疗对HAART使用概率的纵向影响。与未接受抑郁症治疗相比，使用抗抑郁药加心理健康治疗，或单独使用心理健康治疗显著增加HAART使用的可能性。单独使用抗抑郁药与不接受抑郁症治疗没有显著差异。非裔美国妇女和那些使用快克、可卡因或海洛因的人也不太可能使用HAART。这些发现表明，努力提高抑郁症妇女获得精神药物治疗和治疗的机会，可能会增加她们使用最有效的艾滋病毒治疗方法。
This study examines the effects of treated and untreated depressive symptoms on the likelihood of utilization of highly active antiretroviral therapy (HAART) among a multi-site cohort of HIV-infected women who screened positive for probable depression. Data were collected biannually from 1996 through 2002 in a prospective cohort study. Random-effects regression analysis was used to estimate the longitudinal effects of mental health treatment on the probability of HAART utilization, controlling for clinical indicators (CD4 count, viral load), demographic features (race/ ethnicity, income), and behavioural factors (recent crack, cocaine, or heroin use). Use of antidepressants plus mental health therapy, or use of mental health therapy alone significantly increased the probability of HAART utilization, compared to receiving no depression treatment. Use of antidepressants alone did not differ significantly from receiving no depression treatment. African American women and those who used crack, cocaine, or heroin also were less likely to use HAART. These findings suggest that efforts to enhance depressed women's access to psychopharmacologic treatment and therapy may increase their use of the most effective HIV therapies.