Excitatory sympathetic reflex in NaCl-sensitive spontaneously hypertensive rats.
Excitatory sympathetic reflex in NaCl-sensitive spontaneously hypertensive rats.
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氯化钠敏感自发性高血压大鼠的兴奋性交感神经反射。
DOI：
10.1161/01.hyp.22.3.285
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Oparil,S
中科院分区：
文献类型：
--
作者：
Nakamura,Y;Calhoun,DA;Chen,YF;Wyss,JM;Oparil,S
我们以前已经证明了钝反射反应的腰交感神经活动在容量扩张过程中NaCl敏感的自发性高血压大鼠维持基础（1%NaCl）饮食相比，NaCl耐药的自发性高血压大鼠，Wistar-Kyoto大鼠，和Sprague-Dawley大鼠。目前的研究测试的假设，长期摄入高（8%）氯化钠饮食进一步钝化氯化钠敏感的自发性高血压大鼠的心肺反射功能。在1%或8%NaCl饮食3周后，所有四种品系的雄性大鼠在10周龄时用股动脉和静脉插管和腰神经记录电极进行仪器化。两天后，清醒的大鼠输注全血以扩大血容量。NaCl敏感性自发性高血压大鼠维持在1%的NaCl饮食有钝化的神经活动的反应，急性体积扩张相比，控制株。NaCl敏感的自发性高血压大鼠维持在8%的NaCl饮食增加的神经活动反应的体积扩张。在第二个实验中，在麻醉的NaCl敏感性自发性高血压大鼠中重复容量扩张方案，所述大鼠在3周的1%或8%NaCl饮食后经受窦主动脉去神经支配。去窦弓神经后，在体积扩张过程中再次观察到神经活动的增加，在动物喂食8%NaCl饮食。在喂食1%NaCl饮食的动物中，神经活动的变化是可变的。双侧迷走神经切断后兴奋性反应明显减弱。这些研究表明，NaCl敏感性自发性高血压大鼠的血压调节是一个复杂的相互作用的兴奋性和抑制性交感神经反射系统，改变高饮食NaCl暴露。
We have previously demonstrated blunted reflex responses of lumbar sympathetic nerve activity during volume expansion in NaCl-sensitive spontaneously hypertensive rats maintained on basal (1% NaCl) diets compared with NaCl-resistant spontaneously hypertensive rats, Wistar-Kyoto rats, and Sprague-Dawley rats. The current study tested the hypothesis that chronic ingestion of a high (8%) NaCl diet further blunts cardiopulmonary reflex function in the NaCl-sensitive spontaneously hypertensive rat. After 3 weeks of a 1% or 8% NaCl diet, male rats of all four strains were instrumented with femoral arterial and venous cannulas and lumbar nerve recording electrodes at 10 weeks of age. Two days later, conscious rats were infused with whole blood to expand blood volume. NaCl-sensitive spontaneously hypertensive rats maintained on a 1% NaCl diet had blunted responses of nerve activity to acute volume expansion compared with control strains. NaCl-sensitive spontaneously hypertensive rats maintained on an 8% NaCl diet had increases in nerve activity responses to volume expansion. In a second experiment, the volume expansion protocol was repeated in anesthetized NaCl-sensitive spontaneously hypertensive rats that had been subjected to sinoaortic denervation after 3 weeks of a 1% or 8% NaCl diet. After sinoaortic denervation, an increase in nerve activity was again observed during volume expansion in animals fed the 8% NaCl diet. In animals fed the 1% NaCl diet, changes in nerve activity were variable. The excitatory response was significantly reduced after bilateral vagotomy. These studies suggest that blood pressure regulation in NaCl-sensitive spontaneously hypertensive rats is a complex interaction of excitatory and inhibitory sympathetic reflex systems that is altered by high dietary NaCl exposure.