Challenge of Liquid Stressed Protective Materials and Environmental Persistence of Ebola Virus.
Challenge of Liquid Stressed Protective Materials and Environmental Persistence of Ebola Virus.
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DOI：
10.1038/s41598-017-04137-2
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发表时间：
2017-06-29
影响因子：
4.6
通讯作者：
Cook BWM
中科院分区：
文献类型：
--
作者：
Nikiforuk AM;Cutts TA;Theriault SS;Cook BWM
在历史上最大规模的埃博拉病毒爆发之后，专家们试图回答扎伊尔埃博拉病毒是如何在西非出现并造成人际传播链的。受影响国家卫生保健工作者（HCW）的广泛和不及时感染加速了病毒在社区内的传播。在造成这一趋势的原因中，必须考虑到卫生工作者在其职业环境中暴露于病毒。通过调查温度/湿度对病毒环境持久性的影响，并通过模拟饱和度（液体应力）是否允许埃博拉病毒通过个人防护装备渗透，研究了环境条件对埃博拉病毒在西非传播的影响。在27°C和80%相对湿度（RH）条件下，埃博拉-马科纳病毒在疫情环境中发现的个人防护装备和材料上持续时间不到72小时。在干燥（5%，1/21试验）和饱和（33%，7/21试验）PPE样品之间观察到病毒渗透的差异。传染性病毒颗粒通过饱和的特卫强微洁、泰chem QC、全口罩、N95口罩渗透。这些发现建议在防护设备测试标准中加入饱和或类似的液体应力模拟。
After the largest Ebola virus outbreak in history, experts have attempted to answer how the Zaire ebolavirus species emerged in West Africa and caused chains of human-to-human transmission. The widespread and untimely infection of Health Care Workers (HCW) in the affected countries accelerated spread of the virus within the community. Among the reasons attributed to this trend, it must be considered that HCW were exposed to the virus in their occupational environment. The contribution of environmental conditions to the spread of Ebola in West Africa was examined by investigating the effect of temperature/humidity on the virus’s environmental persistence and by modeling if saturation (liquid stress) allows for penetration of Ebola virus through personal protective equipment (PPE). Ebola-Makona virus persisted on PPE and materials found in outbreak settings for less than 72 hours at 27 °C and 80% relative humidity (RH). A difference in virus penetration was observed between dry (5%, 1/21 tests) and saturated (33%, 7/21 tests) samples of PPE. Infectious virus particles penetrated through saturated coupons of Tyvek Micro Clean, Tychem QC, whole surgical masks and N95 respirators. These findings suggest inclusion of saturation or similar liquid stress simulation in protective equipment testing standards.