Characterization of arrangement and expression of the T cell receptor γ locus in the sandbar shark
Characterization of arrangement and expression of the T cell receptor γ locus in the sandbar shark
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DOI：
10.1073/pnas.0811283106
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发表时间：
2009-05-26
影响因子：
11.1
通讯作者：
Marchalonis, John J.
中科院分区：
文献类型：
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作者：
Chen, Hao;Kshirsagar, Sarika;Marchalonis, John J.
IG和T细胞受体（TCR）基因由单独的基因组元件组成，其必须经历重排和连接才能表达功能性蛋白。在免疫系统的进化过程中，这些元素的基因组排列具有相当大的可塑性。在四足动物中，所有的IG和TCR链元件排列为translocon。在硬骨鱼中，IG重链和TCR链是转座子，但轻链基因可能以簇的形式出现。然而，在软骨鱼类中，所有的IG轻链和重链基因排列成簇。这些集群的数量从
Ig and T cell receptor (TCR) genes consist of separate genomic elements, which must undergo rearrangement and joining before a functional protein can be expressed. Considerable plasticity in the genomic arrangement of these elements has occurred during the evolution of the immune system. In tetrapods, all Ig and TCR chain elements are arranged as translocons. In teleosts, the Ig heavy and TCR chains are translocons, but light chain genes may occur as clusters. However, in chondrichthyes, all of the Ig light and heavy chain genes are arranged as clusters. These clusters vary in number from