Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons and Glia for the Elucidation of Pathogenic Mechanisms in Alzheimer's Disease.
Human-Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons and Glia for the Elucidation of Pathogenic Mechanisms in Alzheimer's Disease.
复制标题
人类诱导多能干细胞 (hiPSC) 衍生的神经元和神经胶质细胞用于阐明阿尔茨海默病的致病机制。
DOI：
10.1007/978-1-0716-2655-9_6
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Goldstein,LawrenceSB
中科院分区：
文献类型：
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作者：
Young,JessicaE;Goldstein,LawrenceSB
阿尔茨海默病（Alzheimer's disease，AD）是一种常见的神经退行性疾病，发病机制复杂。在过去的十年中，使用诱导多能干细胞（iPSC）的AD人类模型已经成为了解相关人类细胞类型中疾病发病机制的有力途径。在这篇综述中，我们总结了该领域的现状，以及这项技术如何应用于AD的家族性和散发性研究。我们讨论了患者来源的iPSCs，基因组编辑，神经细胞类型的分化和三维类器官，并推测这类工作的未来，以增加我们对这种毁灭性疾病的理解，并改善其治疗开发。
Alzheimer’s disease (AD) is a common neurodegenerative disorder and a mechanistically complex disease. For the last decade, human models of AD using induced pluripotent stem cells (iPSCs) have emerged as a powerful way to understand disease pathogenesis in relevant human cell types. In this review, we summarize the state of the field and how this technology can apply to studies of both familial and sporadic studies of AD. We discuss patient-derived iPSCs, genome editing, differentiation of neural cell types, and three-dimensional organoids, and speculate on the future of this type of work for increasing our understanding of, and improving therapeutic development for, this devastating disease.