CT, MR, AND SPECT FINDINGS IN A GENERAL PARESIS
CT, MR, AND SPECT FINDINGS IN A GENERAL PARESIS
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DOI：
10.1016/0895-6111(94)90084-1
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发表时间：
1994-11-01
影响因子：
5.7
通讯作者：
KOIZUMI, J
中科院分区：
文献类型：
--
作者：
KAWAI, N;BABA, A;KOIZUMI, J
通过X线计算机断层扫描（CT）、磁共振（MR）和单光子发射计算机断层扫描（SPECT）研究一例全身性轻瘫患者的中枢神经系统变化。 CT和MR显示轻度弥漫性皮质萎缩和侧脑室扩张，无缺血性病变或炎症体征。 另一方面，使用123 I-N-异丙基-p-碘苯丙胺（123 I-IMP）的SPECT显示脑血流量明显减少，尤其是在双侧额叶和颞叶皮质。 抗梅治疗后血流量减少明显改善，与精神障碍的改善相关。 提示SPECT是一种评价轻瘫患者脑功能障碍及抗梅治疗效果的有效方法。
CNS changes in a case with general paresis were investigated by X-ray computed tomography (CT), Magnetic resonance (MR), and single photon emission computed tomography (SPECT). CT and MR showed a mild degree of diffuse cortical atrophy and the dilatation of lateral ventricles with no signs of ischemic lesions or inflammations. On the other hand, SPECT using 123I-N-isopropyl-p-iodoamphetamine (123I-IMP demonstrated marked reduction of the cerebral blood flow especially in the bilateral frontal and temporal cortices. Moreover, the reduction of the blood flow was significantly improved after the antisyphilitic therapy, correlated with the improvement of the mental disorders. These observations suggested that the SPECT is a useful method to evaluate the brain dysfunctions, and to assess the effect of antisyphilitic therapy in the patients with general paresis.