MEMORY FOR SPATIAL LOCATION AS A FUNCTION OF TEMPORAL LAG IN RATS - ROLE OF HIPPOCAMPUS AND MEDIAL PREFRONTAL CORTEX
MEMORY FOR SPATIAL LOCATION AS A FUNCTION OF TEMPORAL LAG IN RATS - ROLE OF HIPPOCAMPUS AND MEDIAL PREFRONTAL CORTEX
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DOI：
10.1016/s0163-1047(05)80065-2
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发表时间：
1994-03-01
期刊：
影响因子：
--
通讯作者：
REYNOLDS, AM
中科院分区：
文献类型：
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作者：
CHIBA, AA;KESNER, RP;REYNOLDS, AM
内侧前额叶皮质，海马，或皮质控制病变的大鼠进行了测试的八臂径向迷宫任务，以检查记忆的时间顺序的空间位置作为一个功能的时间滞后。在每个试验的研究阶段，允许大鼠按照该试验随机选择的顺序访问八个组中的每一个。测试阶段要求大鼠选择两个臂中的哪一个在研究阶段期间访问的臂序列中较早发生。选择作为试验组的组根据时间滞后（0-6）或研究阶段两个试验组之间发生的组数而变化。对照组大鼠在时间滞后为零时的表现是偶然的，但对于其余的滞后，它们的表现高于偶然，在时间滞后超过零后有所改善。在所有滞后的表现，有一些储蓄的项目发生在列表的末尾。内侧前额叶皮质损伤大鼠表现出不太严重的赤字。这些数据的结果支持的概念，海马和内侧前额叶皮层发挥重要作用，在记忆中的时间顺序的空间位置。(C)1994年出版社出版。
Rats with medial prefrontal cortex, hippocampus, or cortical control lesions were tested on an eight-arm radial maze task, in order to examine memory for the temporal order of spatial locations as a function of temporal lag. During the study phase of each trial, rats were allowed to visit each of eight arms once in an order that was randomly selected for that trial. The test phase required the rats to choose which of two arms occurred earlier in the sequence of arms visited during the study phase. The arms selected as test arms varied according to temporal lag (0-6) or the number of arms that occurred between the two test arms in the study phase. The control rats performed at chance at a temporal lag of zero, but their performance was above chance for the remaining lags, improving after the temporal lag exceeded zero. The hippocampal-lesioned rats showed a marked deficit, performing at chance for all lags, with some savings for those items occurring at the end of the list. The medial prefrontal cortex-lesioned rats showed a less severe deficit. The results of these data support the notion that both the hippocampus and the medial prefrontal cortex play significant roles in memory for the temporal order of spatial locations. (C) 1994 Academic Press, Inc.